Botulinum Toxin Type A Alleviates Androgenetic Alopecia by Inhibiting Apoptosis of Dermal Papilla Cells via Targeting Circ_0135062/MiR-506-3p/Bax Axis

    Wuhan Wei, Jingyu Zhang, Yanping Guo … Peisheng Jin

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This study found that botulinum toxin type A may reduce apoptosis in dermal papillary cells induced by dihydrotestosterone through the circ_0135062/miR-506-3p/Bax axis.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on researchsquare.com →
    Discuss this study in the Community →

    Research cited in this study 20

    1. Construction and Functional Analysis of CeRNA Regulatory Network Related to the Development of Secondary Hair Follicles in Inner Mongolia Cashmere Goats Frontiers in Veterinary Science · 2022
    2. Cyanidin 3-O-Arabinoside Suppresses DHT-Induced Dermal Papilla Cell Senescence by Modulating p38-Dependent ER-Mitochondria Contacts Journal of Biomedical Science · 2022
    3. The Potential Role of hsa_circ_0001079 in Androgenetic Alopecia via Sponging hsa-miR-136-5p Journal of Clinical Laboratory Analysis · 2021
    4. Perspectives on MicroRNAs Targeting DKK1 for Developing Hair Regeneration Therapy Cells · 2021
    5. Comprehensive Transcriptome and Methylome Analysis Delineates the Biological Basis of Hair Follicle Development and Wool-Related Traits in Merino Sheep BMC Biology · 2021
    6. Dihydrotestosterone-Induced Hair Regrowth Inhibition by Activating Androgen Receptor in C57BL6 Mice Simulates Androgenetic Alopecia Biomedicine & Pharmacotherapy · 2021
    7. Anti-Androgenetic Alopecia Effect of Policosanol from Chinese Wax by Regulating Abnormal Hormone Levels to Suppress Premature Hair Follicle Entry into the Regression Phase Biomedicine & Pharmacotherapy · 2021
    8. Hair Growth Promoting Effects of 650 nm Red Light Stimulation on Human Hair Follicles and Study of Its Mechanisms via RNA Sequencing Transcriptome Analysis Annals of Dermatology · 2021
    9. The Effect of Intradermal Botulinum Toxin on Androgenetic Alopecia and Its Possible Mechanism Journal of The American Academy of Dermatology · 2020
    10. Effectiveness and Safety of Botulinum Toxin Type A in the Treatment of Androgenetic Alopecia BioMed Research International · 2020
    11. The Peptide AC 2 Isolated from Bacillus-Treated Trapa Japonica Fruit Extract Rescues DHT-Treated Human Dermal Papilla Cells and Mediates mTORC1 Signaling for Autophagy and Apoptosis Suppression Scientific reports · 2019
    12. Systematic Analysis of Non-coding RNAs Involved in the Angora Rabbit Hair Follicle Cycle by RNA Sequencing Frontiers in genetics · 2019
    13. Clinical Profile of Androgenic Alopecia and Its Association with Cardiovascular Risk Factors Indian Journal of Dermatology · 2019
    14. The Effectiveness of Treatments for Androgenetic Alopecia: A Systematic Review and Meta-Analysis Journal of The American Academy of Dermatology · 2017
    15. Safety and Tolerability of the Dual 5-Alpha Reductase Inhibitor Dutasteride in the Treatment of Androgenetic Alopecia Annals of Dermatology · 2016
    16. Genetic Variants at 20p11 Confer Risk to Androgenetic Alopecia in the Chinese Han Population PLOS ONE · 2013
    17. Evaluation of Apoptosis Regulatory Markers in Androgenetic Alopecia Journal of Cosmetic Dermatology · 2010
    18. Treatment of Male Pattern Baldness with Botulinum Toxin: A Pilot Study Plastic and Reconstructive Surgery · 2010
    19. Effect of 5α-Dihydrotestosterone and Testosterone on Apoptosis in Human Dermal Papilla Cells Skin Pharmacology and Physiology · 2006
    20. Simple and Rapid Method to Isolate and Culture Follicular Papillae from Human Scalp Hair Follicles Experimental Dermatology · 2002