Recombinant Type XVII Collagen Promotes Hair Growth by Activating the Wnt/β-Catenin and SHH/GLI Signaling Pathways

    July 2025 in “ Cosmetics
    Yuyao Zhang, Shiyu Yin, Ru Xu, Jiayu Xiao, Yi Rui, Jiahui Mao, Zhiguang Duan, Daidi Fan
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    TLDR Recombinant type XVII collagen may help regrow hair by activating specific cell pathways.
    The study explores the effects of recombinant human type XVII collagen (rhCOL17A1) on hair growth, highlighting its potential as a safer hair restoration treatment. By activating the Wnt/β-catenin and SHH/GLI signaling pathways, rhCOL17A1 enhances the resistance of hair follicle dermal papilla cells to apoptosis and promotes hair regrowth. The research, conducted on 50 male C57BL/6 mice, demonstrated that rhCOL17A1 increases the expression of growth factors such as VEGF, IGF-1, and FGF-7, facilitating the transition of hair follicles from the telogen to anagen phase. These findings suggest that rhCOL17A1 could be a promising therapeutic agent for hair loss, with potential applications in hair care products to support long-term follicular health. Further studies are needed to evaluate its safety and optimal usage.
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