Caizhixuan Hair Tonic Regulates Both Apoptosis and the PI3K/Akt Pathway to Treat Androgenetic Alopecia

    February 2023 in “ PLOS ONE
    Tingting Fang, Ruofei Xu, Shaopeng Sun, Yineng He, Yi Yan, Hongyang Fu, Hongbin Luo, Yi Cao, Maocan Tao
    TLDR Caizhixuan hair tonic helps treat hair loss by promoting hair growth and improving hair follicles.
    The study investigates the effects of Caizhixuan (CZX) hair tonic on androgenetic alopecia (AGA) using a mouse model. CZX was found to promote hair growth and improve hair follicle morphology by regulating the PI3K/Akt and apoptosis pathways. The study identified 69 components in CZX, and network pharmacology suggested that CZX alleviates AGA by upregulating PI3K, Akt, and Bcl-2 expressions while downregulating Bax and caspase-3. These findings were confirmed by RT-qPCR and Western blotting, indicating that CZX treats AGA by modulating these pathways.
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