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    Connarus Semidecandrus Jack Exerts Anti-Alopecia Effects by Targeting 5α-Reductase Activity and an Intrinsic Apoptotic Pathway

    June 2022 in “ Molecules ”
    Won Young Jang, Dong Seon Kim, Sang Hee Park … Jae Youl Cho
    Studysummary This study demonstrated that an ethanol extract of Connarus semidecandrus Jack showed potential anti-androgenic alopecia effects in a testosterone-induced model, suggesting a possible treatment option for hair loss.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 25

    1. Effects of Acanthus Ebracteatus Vahl Extract and Verbascoside on Human Dermal Papilla and Murine Macrophage Scientific Reports · 2022
    2. Tectoridin Stimulates the Activity of Human Dermal Papilla Cells and Promotes Hair Shaft Elongation in Mouse Vibrissae Hair Follicle Culture Molecules · 2022
    3. Application of Ethanol Extracts From Alnus Sibirica Fisch. ex Turcz in Hair Growth Promotion Frontiers in Bioengineering and Biotechnology · 2021
    4. Screening of Hair Growth Promoting Activity of Punica Granatum L. (Pomegranate) Leaves Extracts and Its Potential to Exhibit Antidandruff and Anti-Lice Effect Heliyon · 2021
    5. Red Ginseng Oil Promotes Hair Growth and Protects Skin Against UVC Radiation Journal of Ginseng Research · 2021
    6. Polygonum Multiflorum Extract Supports Hair Growth by Elongating Anagen Phase and Abrogating the Effect of Androgen in Cultured Human Dermal Papilla Cells BMC complementary medicine and therapies · 2020
    7. Effects of a Gintonin-Enriched Fraction on Hair Growth: An In Vitro and In Vivo Study Journal of Ginseng Research · 2019
    8. Tetrahydroxystilbene Glucoside Effectively Prevents Apoptosis-Induced Hair Loss BioMed Research International · 2018
    9. Histological Assessment of Follicular Delivery of Flutamide by Solid Lipid Nanoparticles: Potential Tool for the Treatment of Androgenic Alopecia Drug Development and Industrial Pharmacy · 2015
    10. Inhibition of Rat 5α-Reductase Activity and Testosterone-Induced Sebum Synthesis in Hamster Sebocytes by an Extract of Quercus Acutissima Cortex Evidence-based Complementary and Alternative Medicine · 2015
    11. Emerging Treatments in Alopecia Expert Opinion on Emerging Drugs · 2014
    12. 5α-Reductase Inhibitors Alter Steroid Metabolism and May Contribute to Insulin Resistance, Diabetes, Metabolic Syndrome, and Vascular Disease: A Medical Hypothesis Hormone Molecular Biology and Clinical Investigation · 2014
    13. Minoxidil May Suppress Androgen Receptor-Related Functions Oncotarget · 2014
    14. Beneficial Effects of Astragaloside IV for Hair Loss via Inhibition of Fas/FasL-Mediated Apoptotic Signaling PloS one · 2014
    15. Organic Causes of Erectile Dysfunction in Men Under 40 Urologia Internationalis · 2013
    16. Dermal Papilla Cell Number Specifies Hair Size, Shape, and Cycling, and Its Reduction Causes Follicular Decline Development · 2013
    17. Clinical Biochemistry of Dihydrotestosterone Annals of Clinical Biochemistry · 2013
    18. Characteristics of Androgenetic Alopecia in Asian Populations Annals of Dermatology · 2012
    19. Persistent Sexual Side Effects of Finasteride for Male Pattern Hair Loss The Journal of Sexual Medicine · 2011
    20. Hormonal Basis of Male and Female Androgenic Alopecia: Clinical Relevance Skin Pharmacology and Physiology · 2009
    21. An Open, Randomized, Comparative Study of Oral Finasteride and 5% Topical Minoxidil in Male Androgenetic Alopecia Dermatology · 2004
    22. Treatment of Hyperandrogenic Alopecia in Women Fertility and Sterility · 2003
    23. Molecular Mechanisms of Androgenetic Alopecia Experimental Gerontology · 2002
    24. Analysis of Apoptotic Cell Death in Human Hair Follicles In Vivo and In Vitro Journal of Investigative Dermatology · 1998
    25. Role of 5α-Reductase in Health and Disease Baillière's clinical endocrinology and metabolism · 1994

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