Tectoridin Stimulates the Activity of Human Dermal Papilla Cells and Promotes Hair Shaft Elongation in Mouse Vibrissae Hair Follicle Culture

    January 2022 in “ Molecules
    Gary Ka-Wing Yuen, Bryan Siu-Yin Ho, Shengying Lin, Tina Tingxia Dong, Karl Wah-Keung Tsim
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    TLDR Tectoridin helps human hair cells grow and makes mouse hair longer, suggesting it could treat hair loss.
    The study found that tectoridin, a major isoflavone from the rhizome of Belamcanda chinensis, activates the Wnt/β-catenin signaling pathway, which is crucial for hair growth. In experiments with human dermal papilla cells, tectoridin significantly increased the expression of hair growth-related genes, including AXIN2, LEF-1, β-catenin, IGF-1, and ALP. Additionally, in ex vivo tests using mouse vibrissae hair follicles, tectoridin treatment led to a significant, dose-dependent elongation of hair. These findings suggest that tectoridin could potentially be used as a treatment for hair loss, and further research is needed to understand its multiple pathways of action on the hair follicle and its efficacy in treating androgenetic alopecia.
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