Jiawei Erzhiwan Ameliorates Androgenetic Alopecia by Regulating the SIRT1/JNK/p38 MAPK Pathway

The study explores the effects of Jiawei Erzhiwan (WJWE), a modified traditional Chinese herbal formula, on androgenetic alopecia (AGA) by targeting the SIRT1/JNK/p38 MAPK signaling pathway. Through in vitro and in vivo experiments, including a murine model with 6 mice per group, WJWE was shown to promote hair growth by stimulating the Wnt/β-Catenin pathway and regulating the SIRT1/JNK/p38 MAPK pathway. It increased hair follicle density, enhanced skin thickness, improved dermal papilla cell proliferation, and reduced oxidative stress. The study suggests WJWE as a promising alternative to conventional AGA treatments, with its effects being mediated through the SIRT1 pathway, as confirmed by the diminished benefits when a SIRT1 inhibitor was used.