Xiaozhi Yufa Decoction Ameliorates Androgenetic Alopecia Through Inhibition of MAPK Signaling and Regulation of Lipid Metabolism

    November 2025 in “ Frontiers in Pharmacology
    Yiyu Guo, Jie Wu, Yu Lu, Jian-Ping Qin, Lan-lan Huang, Fengrui Zhang, Xiaomei Zhou, Dengke Yang, Jianzhou Ye
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    TLDR Xiaozhi Yufa decoction may help treat hair loss by improving hair growth and reducing inflammation.
    Xiaozhi Yufa decoction (XZYFD), a Traditional Chinese Medicine formulation, shows promise in treating androgenetic alopecia by modulating androgen metabolism, inhibiting MAPK signaling, and regulating SREBP-1-mediated lipid metabolism. In a testosterone propionate-induced mouse model, XZYFD promoted hair regrowth, improved follicular morphology, and enhanced hormonal profiles while reducing serum lipid levels and inflammatory markers. The study highlights XZYFD's potential benefits for patients with metabolic dysfunction, offering a novel approach to managing progressive hair loss.
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