Association Between Trichoscopic Features, Serum Hormone Levels, and Vitamin D Concentration in Patients With Androgenetic Alopecia in Eastern China: A Cross-Sectional Study

September 2023 in “ Clinical, Cosmetic and Investigational Dermatology ”

Qitao Chen, Qiuwei Tao, Qiang Zhu, Jing Zhu, Xuewen Du

androgenetic alopecia serum sex hormone binding globulin SHBG female pattern hair loss serum 25(OH)D testosterone estradiol dehydroepiandrosterone sulfate DHEAS hair density vellus hair ratio free sex hormones unbound sex hormones vitamin D deficiency AGA vitamin D DHEA vellus hair

From the encyclopedia

Estradiol →

an estrogen promoting hair regrowth more commonly used in women

Vitamin D →

vitamin you should probably be taking for general health might also help your hair a little

Studysummary This study found a significant negative correlation between serum SHBG levels and androgenetic alopecia severity in women, but not in men, while no significant correlation was observed for testosterone, estradiol, dehydroepiandrosterone sulfate, and vitamin D levels with hair loss severity across genders. Our plain-language summary of this paper — not a Tressless recommendation.

The cross-sectional study involved 310 patients with androgenetic alopecia (AGA) and explored the relationship between serum hormones, vitamin D, and AGA severity. The study found a significant negative correlation between serum sex hormone binding globulin (SHBG) levels and the severity of female pattern hair loss. However, no significant correlation was found between serum 25(OH)D, testosterone, estradiol, dehydroepiandrosterone sulfate (DHEAS), and hair density or vellus hair ratio in all AGA patients. The study also found a minimal correlation between serum sex hormone levels and vitamin D in AGA patients, suggesting that free, unbound sex hormones may play a crucial role in female pattern hair loss. The study concluded that serum vitamin D may not be involved in the pathological development of AGA. The study also revealed a high prevalence of early-onset AGA, with most patients being under 30 years old and a common vitamin D deficiency among these patients. The study calls for further research to explore the underlying mechanisms of these observed correlations and to develop targeted treatments.

View this study on dovepress.com →

Discuss this study in the Community →

Research cited in this study

20 / 20 results

research Functional Analysis of Vitamin D Receptor Using Adenovirus Vector

4 citations , February 2023 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

In this study, only Vdr-knockout rats showed both abnormal skin formation and alopecia, which may provide insights into vitamin D receptor function and its role in the hair growth cycle.

The Predictive Value of Midscalp Hair Density and Terminal Hair Percentage in the Severity Evaluation of Female Pattern Hair Loss Assessed by Trichoscan in a Sample of Chinese Population

research The Predictive Value of Midscalp Hair Density and Terminal Hair Percentage in the Severity Evaluation of Female Pattern Hair Loss Assessed by Trichoscan in a Sample of Chinese Population

1 citations , December 2022 in “Clinical, Cosmetic and Investigational Dermatology”

In this study, TrichoScan characteristics, particularly hair density and terminal hair percentage in the midscalp, were found to predictively classify female pattern hair loss in a Chinese population.

research Vitamin D Supplementation for Patients with Alopecia Areata: A Protocol for Systematic Review and Meta-Analysis

4 citations , October 2022 in “Medicine”

Vitamin D might help treat alopecia areata.

research Prevalence of Low Serum Vitamin D Levels in Patients Presenting With Androgenetic Alopecia: A Review

2 citations , December 2021 in “Cureus”

This review discusses the potential link between low serum vitamin D levels and androgenetic alopecia and reports that vitamin D might be useful for diagnosis and treatment, but no new clinical results are included.

research Role of Vitamin D in Hair Loss: A Short Review

14 citations , September 2021 in “Journal of Cosmetic Dermatology”

This review discusses vitamin D's role in hair follicle biology and its association with hair loss but reports no conclusive evidence for its effectiveness as a treatment, indicating the need for further studies.

research Health-Related Quality of Life, Depression, and Self-Esteem in Patients With Androgenetic Alopecia

15 citations , July 2021 in “JAMA Dermatology”

This study found that androgenetic alopecia is significantly associated with moderate impairment of health-related quality of life and emotions, but not with depressive symptoms.

research Is There Any Association Between Clinical and Biochemical Hyperandrogenism in Women With Female Pattern Hair Loss?

1 citations , November 2020 in “Cureus”

This study found that severity of female pattern hair loss in premenopausal women was related to other clinical signs of hyperandrogenism like hirsutism and acne, but not to biochemical measures of hyperandrogenism.

research A Cross-Sectional Study of Plasma Trace Elements and Vitamins Content in Androgenetic Alopecia in Men

3 citations , November 2020 in “Biological Trace Element Research”

This study found that patients with androgenetic alopecia had deficiencies in certain trace elements and vitamins, which were linked to distinct patterns of hair loss connected to androgen levels.

research Study of Serum Vitamin D Levels in Men with Premature Androgenetic Alopecia

8 citations , June 2020 in “International Journal of Dermatology”

This study found a significant correlation between vitamin D deficiency and the severity of androgenetic alopecia in males, suggesting that vitamin D may influence the condition's premature onset.

research New Aspects of Vitamin D Metabolism and Action: Addressing the Skin as Source and Target

378 citations , February 2020 in “Nature Reviews Endocrinology”

research Female Androgenetic Alopecia: An Update on Diagnosis and Management

43 citations , November 2019 in “American Journal of Clinical Dermatology”

This review discusses female androgenetic alopecia, highlighting its diagnostic challenges and management strategies, but it reports no new results.

research Serum Levels of Androgen-Associated Hormones Are Correlated with Curative Effect in Androgenic Alopecia in Young Men

9 citations , October 2018 in “Medical Science Monitor”

In this study, oral finasteride therapy was associated with decreased DHT levels and improved hair loss severity in young male AGA patients, while hormonal changes influenced the curative effect.

research The Role of Vitamin D in Non-Scarring Alopecia

32 citations , December 2017 in “International Journal of Molecular Sciences”

This review suggests that decreased serum 25-hydroxyvitamin D levels may play a role in different types of non-scarring alopecia, but further studies are needed to explore vitamin D supplementation as a therapeutic option.

research Androgenetic Alopecia: A Review

153 citations , March 2017 in “Endocrine”

This review examines recent advances in understanding the pathophysiology and molecular mechanisms of androgenetic alopecia, highlighting two major genetic risk loci, but does not report new clinical findings.

Vitamin D and the Skin: Focus on a Complex Relationship