Is There Any Association Between Clinical and Biochemical Hyperandrogenism in Women With Female Pattern Hair Loss?

    November 2020 in “ Cureus
    Samih A Odhaib, Khalil Al Hamdi, Abbas Ali Mansour
    TLDR Clinical signs of hyperandrogenism are related to female pattern hair loss severity, but biochemical markers are not.
    The study investigated the association between clinical and biochemical hyperandrogenism (HA) in 362 premenopausal women with female pattern hair loss (FPHL). It found that while clinical signs of HA, such as hirsutism and acne, were related to FPHL severity, biochemical markers of HA (like total testosterone, free testosterone, and bioavailable testosterone) were not. Most women had mild FPHL and were overweight or obese. Despite 52% showing biochemical HA, no significant relationship was found between these biochemical parameters and FPHL severity. Other factors like sex hormone-binding globulin (SHBG) and BMI also showed no significant correlation with FPHL severity.
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