Female Pattern Hair Loss

    July 2018 in “ AJGP ”
    Linda S. Chan, David Cook
    TLDR Low-dose oral minoxidil effectively reduces hair loss in women with female pattern hair loss.
    Female pattern hair loss (FPHL) affected 49% of women, with a prevalence of over 32% among adult Australian women of European descent, characterized by hair follicle miniaturization due to genetic and androgen influences. It caused significant psychological and social issues and could indicate systemic illnesses. Risk factors included age, family history, smoking, and high fasting glucose. Diagnosis was clinical, with a characteristic hair thinning pattern. Topical minoxidil was effective in 60% of women but required continuous use. An Australian study of 100 women found that a daily combination of oral minoxidil 0.25 mg and spironolactone 25 mg reduced hair loss and shedding, with some side effects. Spironolactone and cyproterone acetate were effective in promoting hair regrowth, though cyproterone acetate had significant side effects. 5-alpha reductase inhibitors were less effective. The study emphasized the importance of medical history, lab tests, and the psychological impact of FPHL, noting low-dose oral minoxidil as a significant treatment advancement.
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