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    GlossaryBiochemical Hyperandrogenism

    abnormally high androgen levels in the blood

    Biochemical hyperandrogenism refers to a condition where there is an abnormally high level of androgens (male hormones like testosterone) in the blood. This hormonal imbalance can lead to symptoms such as excessive hair growth, acne, and scalp hair thinning, and is often associated with conditions like polycystic ovary syndrome (PCOS).

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      learn Stemoxydine

      chemical from L'Oreal that encourages hair to enter growth phase

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      compound from cruciferous vegetables has some mild effects on DHT

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      community Optimal dose for topical Melatonin

      in Treatment  6 upvotes 1 year ago
      The conversation is about finding the optimal concentration of topical melatonin for hair loss treatment. The user is considering making their own solution and is unsure whether a higher concentration is more effective for deactivating prolactin receptors.

      community A concise, easy-to-understand post on Androgenic Alopecia theory and its practical applications

      in Research/Science  92 upvotes 2 years ago
      The mechanism of Androgenic Alopecia and practical applications of treatments like Minoxidil, Finasteride, RU58841, dermarolling, scalp massages, anti-fungals, progesterone, estrogen, PPAR-γ activators, reducing oxidative stress, and scalp exercises. It explains why DHT is important in AA and how other factors might be involved such as hypoxia, increased DKK-1 expression, morphological changes to the scalp, skull growth during childhood/puberty, and blood flow.

      community Bile Acid-Mediated DHT Dysregulation Hypothesis

      in Research/Science  13 upvotes 1 month ago
      Elevated bile acids can inhibit the enzyme AKR1C2, leading to increased DHT levels, which may accelerate hair loss in those predisposed to androgenetic alopecia. Treatments mentioned include topical minoxidil and finasteride.