November 1986 in “PubMed” In this study, women with male pattern alopecia had significantly lower serum sex hormone binding globulin levels compared to healthy controls, while testosterone levels remained similar.
20 citations
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April 2009 in “Fertility and Sterility”
24 citations
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November 2015 in “Annals of Nutrition and Metabolism” This study found that specific SHBG gene variants and haplotypes are associated with polycystic ovary syndrome, suggesting that SHBG may be a candidate gene for the condition.
91 citations
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December 2017 in “Systems Biology in Reproductive Medicine” This meta-analysis found that lower serum SHBG levels are associated with an increased risk of PCOS, and improving SHBG levels through treatment may reduce PCOS complications.
September 1989 in “PubMed” This study found no significant differences in sex-hormone binding globulin and androgen serum levels between women with stage II androgenetic alopecia and controls, suggesting that genetically-determined androgen sensitivity might play a major role in the condition.