Network Pharmacology Reveals Curcuma Aeruginosa Roxb. Regulates MAPK and HIF-1 Pathways to Treat Androgenetic Alopecia

July 2024 in “ Biology ”

Aaron Marbyn L. Sintos, Heherson S Cabrera

Curcuma aeruginosa Roxb. androgenetic alopecia AGA CASP3 AKT1 AR IL6 PPARG STAT3 HIF1A MAPK3 trans-verbenol myrtenal hormone response HIF-1 pathway MAPK pathway Curcuma aeruginosa

TLDR Curcuma aeruginosa Roxb. may help treat hair loss by affecting specific biological pathways.

The study investigates the potential of Curcuma aeruginosa Roxb. in treating androgenetic alopecia (AGA) by identifying 66 bioactive compounds that target 59 proteins associated with AGA. Key genes such as CASP3, AKT1, AR, IL6, PPARG, STAT3, HIF1A, and MAPK3 were highlighted. The research suggests that C. aeruginosa regulates hormone response and participates in the MAPK and HIF-1 pathways, offering a promising alternative to current AGA treatments with fewer side effects. Further in vivo and in vitro studies are recommended to validate these findings.

View this study on mdpi.com →

Discuss this study in the Community →

Research cited in this study

45 / 45 results

research Psychosocial Impact of Androgenetic Alopecia on Men: A Systematic Review and Meta-Analysis

August 2023 in “Psychology, Health & Medicine”

Hair loss (androgenetic alopecia) mildly to moderately affects men's quality of life but not significantly their mental health.

research Treatment of Androgenetic Alopecia by Exosomes Secreted From Hair Papilla Cells and the Intervention Effect of LTF

August 2023 in “Journal of Cosmetic Dermatology”

Exosomes from hair papilla cells and the Chinese medicine Liao Tuo Fang can potentially promote hair growth and could be used to develop hair growth drugs.

research New Target for Minoxidil in the Treatment of Androgenetic Alopecia

August 2023 in “Drug Design Development and Therapy”

Minoxidil may work for hair loss by reducing androgen sensitivity and altering hormone-related enzymes.

research Hypoxia Inducible Factor-1α Promotes Trichogenic Gene Expression in Human Dermal Papilla Cells

2 citations , January 2023 in “Scientific Reports”

HIF-1α is important for hair growth and could be a treatment target for hair loss.

research A Novel Hair Restoration Technology Counteracts Androgenic Hair Loss and Promotes Hair Growth in a Blinded Clinical Trial

1 citations , January 2023 in “Journal of Clinical Medicine”

A new hair restoration technology was found to effectively increase hair thickness, density, and growth, while reducing hair loss and improving scalp health, with no side effects.

research Inflammatory Complications After Hair Transplantation: Report of 10 Cases

1 citations , July 2022 in “Journal of Cosmetic Dermatology”

Inflammatory complications are rare after hair transplants but can happen months later, and checking for skin conditions before surgery is important.

research Alpinetin Promotes Hair Regeneration via Activating Hair Follicle Stem Cells

11 citations , May 2022 in “Chinese medicine”

Alpinetin helps grow hair by turning on hair stem cells and is safe for use.

research Exploring the Effects of Chinese Herbal Ingredients on the Signaling Pathway of Alopecia and Screening Effective Compounds

5 citations , April 2022 in “Journal of Ethnopharmacology”

Chinese herbal medicine can help treat hair loss by promoting hair growth and preventing cell death, maintaining a balance between hair growth and loss.

research Phytochemistry and Biological Activities of Curcuma Aeruginosa (Roxb.)

March 2022 in “Indonesian Journal of Chemistry”

Curcuma aeruginosa has various chemical components and health benefits.

Cyanidin 3-O-Arabinoside Suppresses DHT-Induced Dermal Papilla Cell Senescence by Modulating p38-Dependent ER-Mitochondria Contacts

research Cyanidin 3-O-Arabinoside Suppresses DHT-Induced Dermal Papilla Cell Senescence by Modulating p38-Dependent ER-Mitochondria Contacts

14 citations , March 2022 in “Journal of Biomedical Science”

Cyanidin 3-O-arabinoside may help treat a common form of hair loss by protecting cells against aging and improving cell function.

Androgen Receptor-Mediated Paracrine Signaling Induces Regression of Blood Vessels in the Dermal Papilla in Androgenetic Alopecia

research Androgen Receptor-Mediated Paracrine Signaling Induces Regression of Blood Vessels in the Dermal Papilla in Androgenetic Alopecia

6 citations , January 2022 in “Journal of Investigative Dermatology”

Male pattern baldness is linked to higher levels of a certain receptor in the scalp, which leads to the shrinking of blood vessels and hair loss. Early treatment targeting this receptor could be more effective.

research Corticosterone Inhibits GAS6 to Govern Hair Follicle Stem-Cell Quiescence

77 citations , March 2021 in “Nature”

Stress hormone corticosterone blocks a growth factor to slow down hair stem cell activity and hair growth.

research Myristoleic Acid Promotes Anagen Signaling by Autophagy Through Activating Wnt/β-Catenin and ERK Pathways in Dermal Papilla Cells

8 citations , February 2021 in “Biomolecules & therapeutics”

Myristoleic acid helps hair growth by boosting cell growth and recycling processes in hair follicle cells.

research A Case of Contact Allergic Dermatitis to Topical Minoxidil

7 citations , January 2021 in “Cureus”

A woman had an allergic skin reaction to a hair loss treatment containing minoxidil and should not use it.

research Quercitrin Stimulates Hair Growth with Enhanced Expression of Growth Factors via Activation of MAPK/CREB Signaling Pathway

25 citations , September 2020 in “Molecules”

Quercitrin may help treat hair loss by promoting hair growth and improving cell health.

research Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss

86 citations , July 2020 in “International Journal of Molecular Sciences”

Activating the Wnt/β-catenin pathway could lead to new hair loss treatments.

research PI3K/Akt Signaling Pathway Is Essential for De Novo Hair Follicle Regeneration

30 citations , April 2020 in “Stem Cell Research & Therapy”

PI3K/Akt pathway is crucial for hair growth and regeneration.

research HIF-1α Stimulators Function Equally to Leading Hair Loss Agents in Enhancing Dermal Papilla Growth

6 citations , January 2020 in “Skin Pharmacology and Physiology”

HIF-1α stimulators, like deferiprone, work as well as popular hair loss treatments, minoxidil and caffeine, in promoting hair growth.

research Shikimic Acid, a Mannose Bioisostere, Promotes Hair Growth with the Induction of Anagen Hair Cycle.

35 citations , November 2019 in “Scientific Reports”

Lactoferrin Promotes Hair Growth in Mice and Increases Dermal Papilla Cell Proliferation Through Erk/Akt and Wnt Signaling Pathways

research Lactoferrin Promotes Hair Growth in Mice and Increases Dermal Papilla Cell Proliferation Through Erk/Akt and Wnt Signaling Pathways

18 citations , April 2019 in “Archives of Dermatological Research”

Lactoferrin helps mice grow hair by increasing cell growth and hair follicle development.

research Dickkopf-1 Expression in Androgenetic Alopecia and Alopecia Areata in Male Patients

9 citations , January 2019 in “American Journal of Dermatopathology”

DKK-1 gene linked to hair loss in AGA and AA patients; more research needed for potential therapy.

research Safety Concerns When Using Novel Medications to Treat Alopecia

23 citations , October 2018 in “Expert Opinion on Drug Safety”

Consider benefits and risks of new alopecia treatments for safety.

research Finasteride and Erectile Dysfunction in Patients with Benign Prostatic Hyperplasia or Male Androgenetic Alopecia

20 citations , August 2018 in “The World Journal of Men's Health”

Finasteride may increase erectile dysfunction risk in patients with benign prostatic hyperplasia.

research Peroxisome Proliferator-Activated Receptor-Gamma Mediated Signaling Regulates Mitochondrial Energy Metabolism in Human Hair Follicle Epithelium

17 citations , February 2018 in “Journal of Investigative Dermatology”

PPAR-γ signaling improves mitochondrial function in hair follicles, potentially affecting hair growth and aging.

research Minoxidil Induction of VEGF Is Mediated by Inhibition of HIF-Prolyl Hydroxylase

22 citations , December 2017 in “International Journal of Molecular Sciences”

Minoxidil boosts hair growth by increasing blood flow and nutrients to hair follicles.

research Evaluation of the Expression of Genes Associated with Inflammation and Apoptosis in Androgenetic Alopecia by Targeted RNA-Seq

8 citations , December 2017 in “Skin appendage disorders”

WNT7A gene expression is higher in early stages of androgenetic alopecia, showing the role of WNT pathway, apoptosis, and inflammation in the disorder.

Germacrone and Sesquiterpene-Enriched Extracts from Curcuma Aeruginosa Roxb. Increase Skin Penetration of Minoxidil, a Hair Growth Promoter

research Germacrone and Sesquiterpene-Enriched Extracts from Curcuma Aeruginosa Roxb. Increase Skin Penetration of Minoxidil, a Hair Growth Promoter

15 citations , November 2017 in “Drug Delivery and Translational Research”

Certain extracts from Curcuma aeruginosa Roxb. and germacrone can boost the skin's absorption of minoxidil, a hair growth promoter, making it more effective.

research Androgens and Androgen Receptor Action in Skin and Hair Follicles

100 citations , September 2017 in “Molecular and Cellular Endocrinology”

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

An Analysis of Gene Expression Data Involving Examination of Signaling Pathways Activation Reveals New Insights into the Mechanism of Action of Minoxidil Topical Foam in Men with Androgenetic Alopecia

research An Analysis of Gene Expression Data Involving Examination of Signaling Pathways Activation Reveals New Insights into the Mechanism of Action of Minoxidil Topical Foam in Men with Androgenetic Alopecia

12 citations , June 2017 in “Cell Cycle”

Minoxidil foam helps hair growth by increasing good proteins and decreasing bad pathways in men with hair loss.

research Mechanism of Action of Herbs and Their Active Constituents Used in Hair Loss Treatment

47 citations , August 2016 in “Fitoterapia”

Some herbs and their components might help treat hair loss by affecting various biological pathways, but more research and regulation are needed.

research Gab1 and MAPK Signaling Are Essential in the Hair Cycle and Hair Follicle Stem Cell Quiescence

36 citations , October 2015 in “Cell reports”

Gab1 protein is crucial for hair growth and stem cell renewal, and Mapk signaling helps maintain these processes.

research HIF-2α/ARNT Complex Regulates Hair Development via Induction of p21 Waf1/Cip1 and p27 Kip1

4 citations , March 2014 in “The FASEB Journal”

The HIF-2α/ARNT complex is important for hair follicle development by controlling cell growth.

research Constitutive Stat3 Activation Alters Behavior of Hair Follicle Stem and Progenitor Cell Populations

23 citations , September 2013 in “Molecular Carcinogenesis”

Increased Stat3 activity reduces hair follicle stem cells and boosts other stem/progenitor cells.

research Anti-Androgenic Effect of Sesquiterpenes Isolated from the Rhizomes of Curcuma Aeruginosa Roxb.

44 citations , March 2012 in “Fitoterapia”

Germacrone from Curcuma aeruginosa may help treat conditions related to male hormones by blocking a specific enzyme.

research Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia

205 citations , March 2012 in “Science Translational Medicine”

PGD2 stops hair growth and is higher in bald men with AGA.

Curcuma Aeruginosa, A Novel Botanically Derived 5α-Reductase Inhibitor In The Treatment Of Male-Pattern Baldness: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study

research Curcuma Aeruginosa, A Novel Botanically Derived 5α-Reductase Inhibitor In The Treatment Of Male-Pattern Baldness: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study

34 citations , July 2011 in “Journal of Dermatological Treatment”

Curcuma aeruginosa extract combined with minoxidil effectively treats male-pattern baldness.

research Hair Transplantation: Causes, Techniques, and Future Prospects

January 2010 in “Elsevier eBooks”

Hair transplantation is a treatment for hair loss mainly caused by genetics, with various techniques and potential complications, and results visible after 8-12 months.

research Targeted Disruption of Stat3 Reveals a Major Role for Follicular Stem Cells in Skin Tumor Initiation

49 citations , October 2009 in “Cancer research”

Disrupting Stat3 in hair follicle stem cells greatly reduces skin tumor formation.

research Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes

171 citations , July 2007 in “Journal of Investigative Dermatology”

A substance called DKK-1 increases in balding areas and causes hair cells to die when exposed to DHT.

research Effect of 5α-Dihydrotestosterone and Testosterone on Apoptosis in Human Dermal Papilla Cells

58 citations , January 2006 in “Skin Pharmacology and Physiology”

High levels of testosterone and 5α-DHT can lead to cell death in cells important for hair growth.

research Polymorphism of the Androgen Receptor Gene Is Associated with Male Pattern Baldness

299 citations , March 2001 in “Journal of Investigative Dermatology”

research Two Distinct Signaling Pathways in Hair Cycle Induction: Stat3-Dependent and Independent Pathways

73 citations , November 2000 in “Proceedings of the National Academy of Sciences of the United States of America”

There are two ways to start hair growth: one needs Stat3 and the other does not, but both need PI3K activation.

research Balding Hair Follicle Dermal Papilla Cells Contain Higher Levels of Androgen Receptors Than Those From Non-Balding Scalp

227 citations , January 1998 in “Journal of Endocrinology”

Cells from balding scalps have more androgen receptors than cells from non-balding scalps.

Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

research Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

416 citations , September 1997 in “Journal of Investigative Dermatology”

People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.

research An Estrogen Receptor Pathway Regulates the Telogen-Anagen Hair Follicle Transition and Influences Epidermal Cell Proliferation

154 citations , October 1996 in “Proceedings of the National Academy of Sciences of the United States of America”

Estrogen affects hair growth and skin cell multiplication.

Similar Research

5 / 218 results

The Extract of Periplaneta Americana Promotes Hair Regrowth in Mice with Alopecia by Regulating the FOXO/PI3K/AKT Signaling Pathway and Skin Microbiota

research The Extract of Periplaneta Americana Promotes Hair Regrowth in Mice with Alopecia by Regulating the FOXO/PI3K/AKT Signaling Pathway and Skin Microbiota

August 2025 in “Current Issues in Molecular Biology”

Periplaneta americana extract helps hair regrowth in mice with alopecia.

research Curcuma Aeruginosa, A Novel Botanically Derived 5α-Reductase Inhibitor In The Treatment Of Male-Pattern Baldness: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study

34 citations , July 2011 in “Journal of Dermatological Treatment”

Curcuma aeruginosa extract combined with minoxidil effectively treats male-pattern baldness.

The New Paradigm for Androgenetic Alopecia and Plant-Based Folk Remedies: 5α-Reductase Inhibition, Reversal of Secondary Microinflammation, and Improving Insulin Resistance

research The New Paradigm for Androgenetic Alopecia and Plant-Based Folk Remedies: 5α-Reductase Inhibition, Reversal of Secondary Microinflammation, and Improving Insulin Resistance

16 citations , September 2018 in “Journal of Ethnopharmacology”

Plant-based remedies may treat hair loss by reducing inflammation and improving insulin resistance.

research Complementary and Alternative Treatments for Alopecia: A Comprehensive Review

40 citations , August 2018 in “Skin appendage disorders”

Some alternative treatments for hair loss might work, but more research is needed.

research The Potential of Androgenic Alopecia Management from Plant Derivatives

1 citations , August 2020 in “Food Research”

Plant extracts like Avicennia marina, Boehmeria nipononivea, and Camellia sinensis could potentially treat hair loss with fewer side effects than synthetic drugs.