Hair Transplantation: Causes, Techniques, and Future Prospects

January 2010 in “ Elsevier eBooks ”

David M. Schwartzenfeld, Joseph Karamikian

TLDR Hair transplantation is a treatment for hair loss mainly caused by genetics, with various techniques and potential complications, and results visible after 8-12 months.

The document from January 1, 2010, discusses hair transplantation, identifying androgenic alopecia (AA) as the cause of over 95% of pattern hair loss, influenced by testosterone and dihydrotestosterone (DHT). Other causes of hair loss include metabolic, infectious, inflammatory, autoimmune disorders, trauma, and medications. It acknowledges Dr. O'Tar T. Norwood's contributions, particularly the Norwood Classification for male pattern baldness. Hair transplantation requires careful planning of the hairline, donor area harvesting, and managing the patient's donor supply, with complications such as edema, folliculitis, infection, and wound dehiscence possible. Medical treatments mentioned include finasteride and minoxidil, with future prospects like cloning and nanotechnology. Follicular unit extraction (FUE) is described as having advantages like shorter recovery and no linear scar but also disadvantages like higher rates of follicle damage and a limit of 400 to 600 grafts per session. Full transplant results can take 8 to 12 months to appear.

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Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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Scalp tension potentially affecting hair loss, and potential treatments for male pattern baldness such as Minoxidil, Finasteride and RU58841. Evidence from a study was discussed which suggests that the cause of MPB lies within the follicle itself and is not dependent on its surrounding environment.

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