Germacrone and Sesquiterpene-Enriched Extracts from Curcuma Aeruginosa Roxb. Increase Skin Penetration of Minoxidil, a Hair Growth Promoter

    November 2017 in “ Drug Delivery and Translational Research ”
    Jukkarin Srivilai, Neti Waranuch, Anothai Tangsumranjit … Kornkanok Ingkaninan
    Studysummary This study found that co-applying Curcuma aeruginosa extract or essential oil with minoxidil significantly increased minoxidil's skin penetration in an ex vivo setting, suggesting an improved topical treatment strategy for androgenic alopecia with greater efficacy and the potential for lower minoxidil doses.
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    Research cited in this study 12

    1. Stability Studies of Antiandrogenic Compounds in Curcuma Aeruginosa Roxb. Extract Journal of Pharmacy and Pharmacology · 2014
    2. Androgenetic Alopecia: An Evidence-Based Treatment Update American Journal of Clinical Dermatology · 2014
    3. Anti-Androgenic Effect of Sesquiterpenes Isolated from the Rhizomes of Curcuma Aeruginosa Roxb. Fitoterapia · 2012
    4. Finasteride and Sexual Side Effects Indian Dermatology Online Journal · 2012
    5. Curcuma Aeruginosa, A Novel Botanically Derived 5α-Reductase Inhibitor In The Treatment Of Male-Pattern Baldness: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study Journal of Dermatological Treatment · 2011
    6. Persistent Sexual Side Effects of Finasteride for Male Pattern Hair Loss The Journal of Sexual Medicine · 2011
    7. Formulation and In Vitro Assessment of Minoxidil Niosomes for Enhanced Skin Delivery International Journal of Pharmaceutics · 2009
    8. Male Androgenetic Alopecia The Journal of Men's Health & Gender · 2004
    9. Evaluation of Sexual Function With an International Index of Erectile Function in Subjects Taking Finasteride for Androgenetic Alopecia Archives of Dermatology · 2004
    10. A Randomized, Placebo-Controlled Trial of 5% and 2% Topical Minoxidil Solutions in the Treatment of Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2004
    11. Finasteride in the Treatment of Men with Androgenetic Alopecia Journal of The American Academy of Dermatology · 1998
    12. Bioavailability Assessment of Topical Delivery Systems: Effect of Vehicle Evaporation Upon In Vitro Delivery of Minoxidil from Solution Formulations International Journal of Pharmaceutics · 1989

    Related research 3

    1. Minoxidil Skin Delivery from Nanoemulsion Formulations Containing Eucalyptol or Oleic Acid: Enhanced Diffusivity and Follicular Targeting Pharmaceutics · 2018
    2. Germacrone and Sesquiterpene-Enriched Extracts from Curcuma Aeruginosa Roxb. Increase Skin Penetration of Minoxidil, a Hair Growth Promoter Drug Delivery and Translational Research · 2017
    3. Relative Uptake of Minoxidil Into Appendages and Stratum Corneum and Permeation Through Human Skin In Vitro Journal of Pharmaceutical Sciences · 2009