Bioavailability Assessment of Topical Delivery Systems: Effect of Vehicle Evaporation Upon In Vitro Delivery of Minoxidil from Solution Formulations
October 1989
in “
International Journal of Pharmaceutics
”
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Studysummary This study found that topical minoxidil solutions showed the highest skin permeation at 3-4% concentrations, with crystallization occurring at a 5% concentration due to vehicle component evaporation.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
This study examines how the evaporation of the vehicle affects the delivery of minoxidil in topical delivery systems. The study found that the bioavailability of minoxidil in topical delivery systems decreases as the vehicle evaporates. The rate of minoxidil delivery in topical systems decreases as the vehicle evaporates, and the concentration of minoxidil in the vehicle affects its absorption. The study recommends careful consideration of minoxidil concentration in topical delivery systems to optimize bioavailability. The thermodynamic activity of the drug in the vehicle is a major factor in determining how much of the drug gets through the skin.
