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GlossaryCaspase-3 (CASP3)

enzyme that plays a key role in programmed cell death

Caspase-3 is a crucial enzyme in the process of apoptosis, which is the programmed cell death that helps maintain healthy tissue by removing damaged or unnecessary cells. Often referred to as the "executioner" caspase, it plays a key role in dismantling cellular components during apoptosis, ensuring that cells die in a controlled manner without causing harm to surrounding tissues.

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research Exploring the Mechanisms and Molecular Targets of Taohong Siwu Decoction for the Treatment of Androgenetic Alopecia Based on Network Analysis and Molecular Docking

1 citations, July 2022 in “Clinical, Cosmetic and Investigational Dermatology”

Taohong Siwu Decoction may help treat hair loss by targeting multiple genes and pathways.

research Network Pharmacology Reveals Curcuma Aeruginosa Roxb. Regulates MAPK and HIF-1 Pathways to Treat Androgenetic Alopecia

July 2024 in “Biology”

Curcuma aeruginosa Roxb. may help treat hair loss by affecting specific biological pathways.

research Treatment of Androgenetic Alopecia by Exosomes Secreted From Hair Papilla Cells and the Intervention Effect of LTF

August 2023 in “Journal of Cosmetic Dermatology”

Exosomes from hair papilla cells and the Chinese medicine Liao Tuo Fang can potentially promote hair growth and could be used to develop hair growth drugs.

research Pathobiology of Chemotherapy-Induced Hair Loss

218 citations, January 2013 in “The Lancet Oncology”

Chemotherapy causes hair loss by damaging hair follicles and stem cells, with more research needed for prevention and treatment.

research Apoptosis May Explain the Pharmacological Mode of Action and Adverse Effects of Isotretinoin, Including Teratogenicity

66 citations, January 2017 in “Acta dermato-venereologica”

Isotretinoin's effects and side effects, like birth defects and depression, might be due to it causing cell death in various cells.

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community US only: $5/month unlimited generic Fin and Dut

in Finasteride/Dutasteride 49 upvotes 2 weeks ago

In the US, Amazon Pharmacy offers unlimited generic Finasteride and Dutasteride for $5/month with RxPass, requiring an Amazon Prime membership and a prescription. Alternatives include Costco and other pharmacies, but prices and availability vary.

community Don't use PP405 from everychem. it is likely fake.

in Research/Science 58 upvotes 1 month ago

PP405 from Everychem is likely fake and potentially harmful, with concerns about its stability and the risk of using the wrong MPC inhibitor, which could damage hair follicles. The real PP405 was studied under strict conditions, and DIY attempts are discouraged due to unknown formulation and quality control.

community Why microneedling can ruin a hair transplant

in Microneedling 14 upvotes 5 months ago

Microneedling's effectiveness for hair growth is debated, with some suggesting it enhances minoxidil absorption, but evidence is inconclusive. Concerns exist about its impact on hair transplants, and opinions vary on its use with other treatments like RU58841 and stemoxydine.

community 1 year of finasteride and 5 months of oral minoxidil, nizoral and microneedling

in Progress Pictures 54 upvotes 2 years ago

User shared 1-year finasteride and 5-month oral minoxidil, nizoral, and microneedling progress. Reply suggests full results may appear after 1-2 years, and results look promising.

community Hair loss causes are still a myth.

in Chat 17 upvotes 3 years ago

The conversation discusses the complexity of hair loss causes, suggesting that DHT sensitivity alone doesn't fully explain it. Treatments mentioned include finasteride and dutasteride.

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