HIF-2α/ARNT Complex Regulates Hair Development via Induction of p21 Waf1/Cip1 and p27 Kip1

    March 2014 in “ The FASEB Journal ”
    Yuko Imamura, Shuhei Tomita, Masaki Imanishi … Toshiaki Takahashi
    Studysummary This study observed that deleting ARNT in keratinocytes of mice reduced zigzag hair production and altered hair follicle differentiation, likely by affecting the expression of specific cyclin-dependent kinase inhibitors.
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    Research cited in this study 4

    1. Scratching the Surface of Skin Development Nature · 2007
    2. Bone Morphogenetic Protein Signaling Regulates the Size of Hair Follicles and Modulates the Expression of Cell Cycle-Associated Genes Proceedings of the National Academy of Sciences of the United States of America · 2006
    3. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    4. Differences in Hair Follicle Dermal Papilla Volume Are Due to Extracellular Matrix Volume and Cell Number: Implications for the Control of Hair Follicle Size and Androgen Responses Journal of Investigative Dermatology · 1999