TLDR The HIF-2α/ARNT complex is important for hair follicle development by controlling cell growth.
The study explored the influence of the HIF-2α/ARNT complex on hair follicle development by examining wild-type and keratinocyte-specific Arnt-knockout mice. It was discovered that HIF-2α and ARNT are highly expressed in the hair follicle's precortex area and that the absence of ARNT led to larger anagen hair follicles and fewer zigzag hairs due to decreased HIF-2α expression and increased expression of the cell cycle inhibitors p21 Waf1/Cip1 and p27 Kip1. The findings suggest that the HIF-2α/ARNT complex is crucial for regulating hair follicle development and differentiation, potentially offering insights into hair growth disorders. The study involved 3 to 6 mice per group across multiple independent experiments.
788 citations,
February 2007 in “Nature” The document concludes that skin stem cells are important for hair growth and wound healing, and could be used in regenerative medicine.
92 citations,
November 2006 in “Proceedings of the National Academy of Sciences of the United States of America” BMP signaling controls hair follicle size and cell growth by affecting cell cycle genes.
854 citations,
February 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” Understanding hair follicle development can help treat hair loss, skin regeneration, and certain skin cancers.
231 citations,
December 1999 in “Journal of Investigative Dermatology” Hair follicle size is mainly influenced by the number of cells and extracellular matrix volume, with cell number having a larger impact.
Curcuma aeruginosa Roxb. may help treat hair loss by affecting specific biological pathways.
33 citations,
August 2013 in “Journal of Investigative Dermatology” Human hair follicle stem cells show signs of low oxygen levels, which may be important for hair growth and preventing baldness.
5 citations,
March 2023 in “Archives of dermatological research” Increased HIF-1α is linked to the inflammation and severity of hidradenitis suppurativa, suggesting treatments that lower HIF-1α could help.
January 2018 in “Stem cell biology and regenerative medicine” The nucleus is key in controlling skin growth and repair by coordinating signals, gene regulators, and epigenetic changes.
March 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” Removing a specific gene in certain skin cells causes hair loss on the body by disrupting normal hair development.
