Qu-Shi-Yu-Fa Decoction Promotes Hair Cycle and Keratinization by Upregulating Foxn1 and Tgm3 to Treat Androgenetic Alopecia

January 2024

Mingxi Zhu, Yuan Fang, Ying Huang, W. QIU, Ling Ning, Yanan Li, Chengwei Zhu, Xiaoyu Song, Yuanyuan Wu, Wei Zou, Aiyun Wang, Lu Yin

Qu-shi-yu-fa Decoction androgenetic alopecia FOXN1 TGM3 hair follicle telogen phase anagen phase hair bulb PI3K-AKT pathway MAPK pathway hair cycle keratinization hair follicle papilla cells QSYF AGA

TLDR Qu-shi-yu-fa Decoction may help treat hair loss by promoting hair growth and strengthening hair follicles.

The study investigates the effects of Qu-shi-yu-fa Decoction (QSYF) on androgenetic alopecia (AGA) using a mouse model. QSYF was found to significantly accelerate hair regeneration by promoting the transition of hair follicles from the telogen to anagen phase, increasing hair bulb diameter and skin thickness. The decoction upregulated the expression of FOXN1 and TGM3, enhancing the proliferative activity of hair follicle papilla cells and regulating the hair cycle and keratinization process. Additionally, QSYF activated key signaling pathways such as PI3K-AKT and MAPK, demonstrating its therapeutic potential for AGA. The study highlights QSYF's potential as a novel treatment strategy for AGA by identifying new therapeutic targets.

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370 citations, September 1999 in “The New England Journal of Medicine”

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