Studying Hair Growth Cycle and Its Effects on Mouse Skin

August 2023 in “ Journal of Investigative Dermatology ”

Wei‐Hung Wang, Raúl Ramos, Kang‐Yu Tai, Yun-Shan Wu, Tso-Yu Chang, Jia-Yu Yan, Maksim V. Plikus, Ji Won Oh, Sung‐Jan Lin

hair growth cycle anagen quantitative hair plucking depilation murine studies skin injuries

Studysummary Understanding the hair growth cycle in mice is crucial for accurate research, as it affects study results and requires careful timing and methods.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on pmc.ncbi.nlm.nih.gov →

Discuss this study in the Community →

Research cited in this study

9 / 9 results

research Hedgehog Signaling Reprograms Hair Follicle Niche Fibroblasts to a Hyper-Activated State

25 citations , June 2022 in “Developmental cell”

In this study, Hedgehog signaling in dermal papilla fibroblasts was found to accelerate hair growth and induce follicle multiplication in mice via the SCUBE3/TGF-β pathway, with some effects observed in human scalp hair follicles.

research Hair Follicles’ Transit-Amplifying Cells Govern Concurrent Dermal Adipocyte Production Through Sonic Hedgehog

75 citations , October 2016 in “Genes & Development”

This study found that Sonic Hedgehog secreted by hair follicle transit-amplifying cells is essential for dermal adipogenesis and hair follicle growth by acting on adipocyte precursors.

research Organ-Level Quorum Sensing Directs Regeneration in Hair Stem Cell Populations

236 citations , April 2015 in “Cell”

This study found that patterned hair plucking in mice triggers a collective regeneration response in nearby unplucked hair follicles via a quorum sensing mechanism involving immune signaling.

research Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells

175 citations , December 2014 in “PLoS Biology”

This study found that macrophages near hair follicles contribute to the activation of skin epithelial stem cells in mice, suggesting a novel role for macrophages in regulating hair growth.

research Regenerative Hair Waves in Aging Mice and Extra-Follicular Modulators Follistatin, Dkk1, and Sfrp4

75 citations , March 2014 in “Journal of Investigative Dermatology”

This study found that aging mice experience slower and more fragmented hair cycle waves, but transplanting aged skin to a young host can partially restore hair cycling, implicating extracellular factors.

research Mesenchymal–Epithelial Interactions During Hair Follicle Morphogenesis and Cycling

300 citations , August 2012 in “Seminars in Cell & Developmental Biology”

This review discusses mesenchymal–epithelial interactions in hair follicle development and cycling, highlighting recent insights without reporting new experimental results.

research Hair Cycle Resting Phase Is Regulated by Cyclic Epithelial FGF18 Signaling

158 citations , February 2012 in “Journal of Investigative Dermatology”

FGF18 helps keep hair in its resting phase, affecting hair growth cycles.

research Self-Organizing and Stochastic Behaviors During the Regeneration of Hair Stem Cells

176 citations , April 2011 in “Science”

This study found that in a population of hair follicles, regenerative cycling stages are regulated by both intrinsic and extrinsic signals, with WNT/BMP signaling mediating interactions among follicles for adaptability.

research Complex Hair Cycle Domain Patterns and Regenerative Hair Waves in Living Rodents

127 citations , December 2007 in “Journal of Investigative Dermatology”

This review examines regenerative hair waves and complex hair cycle domains in transgenic mice, highlighting how these dynamic processes contribute to skin regeneration and the physiological regulation of organs, but reports no new experimental results.