Subcutaneous Injection of Genetically Engineered Exosomes for Androgenic Alopecia Treatment

    Yukun Liu, Yonghong Liu, Jing Zhao, Tianyi Deng, Yinyin Ben, Ruitao Lu, Xusha Zhou, Runbin Yan, Xiaoqing Chen, Jian V. Zhang, Grace Guoying Zhou
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    TLDR EX104 shows promise in treating hair loss by promoting hair growth and improving scalp health.
    The study explores the potential of EX104, a genetically engineered exosome encapsulating VEGFA, WNT10B, and FGF7, for treating androgenic alopecia (AGA) in C57BL/6 mouse models. EX104 was found to enhance dermal papilla cell proliferation, counteract the effects of dihydrotestosterone, and improve the hair follicle microenvironment by increasing blood vessel formation and hair follicle proliferation. The treatment significantly increased hair coverage, reversed follicular miniaturization, and reduced androgen receptor mRNA expression, suggesting it effectively addresses the pathological processes of AGA. While the results are promising, further research is needed to confirm its efficacy and safety in humans.
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