Hydrogel Forming Microneedles Loaded With VEGF and Ritlecitinib/Polyhydroxyalkanoates Nanoparticles for Mini-Invasive Androgenetic Alopecia Treatment

    August 2024 in “ Bioactive materials
    Yanwen Ding, Y. B. Li, Zhiwei Zhang, Jin-Wei Dao, Dai‐Xu Wei, Dai‐Xu Wei, Dai‐Xu Wei
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    TLDR New microneedle treatment with growth factors and a hair loss drug shows better and faster hair growth results than current treatments.
    The study introduces a new treatment for Androgenetic alopecia (AGA) using a hyaluronic acid-based hydrogel-formed microneedle (MN) loaded with vascular endothelial growth factor (VEGF) and a new hair loss drug, Ritlecitinib, encapsulated in slowly biodegradable polyhydroxyalkanoates nanoparticles. This combination improved the microneedles' mechanical characteristics and skin penetration efficiency. The microneedles promoted angiogenesis and improved the immune microenvironment around the hair follicle, fostering hair follicle cell proliferation and development. Compared to minoxidil, the microneedles showed a faster onset of the anagen phase, improved hair quality, and greater coverage in AGA model mice, suggesting a safer and more efficient strategy for AGA treatment.
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