Vascular Endothelial Growth Factor And Its Receptor May Be One Molecular Mechanism For Androgenetic Alopecia
March 2009
in “
Medical Hypotheses
”
![Image of study](/images/research/b5b45988-51df-4f7a-82f0-35eb9aad685d/medium/2864.jpg)
TLDR VEGF and its receptor might cause hair loss.
This article suggests that vascular endothelial growth factor (VEGF) and its receptor may be a molecular mechanism for androgenetic alopecia (AGA). Dihydrotestosterone (DHT) binds to androgen receptors in hair follicles, down-regulating the expression of VEGF in dermal papilla cells (DPC), which leads to hair loss. The document also briefly mentions the role of serotonin in viral hepatitis and proposes a modification to the rapid tryptophan depletion (RTD) procedure to potentially reduce virus persistence and immunopathology.