Screening of Anti-Hair Loss Plant Raw Materials Based on Reverse Network Pharmacology and Experimental Validation

    January 2025 in “ Current Issues in Molecular Biology ”
    Jiajia Xu, Congfen He, Rui Tian
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    TLDR Certain plant extracts may help prevent hair loss and promote hair growth safely.
    The study explores the anti-hair loss potential of plant extracts, including licorice, salvia miltiorrhiza, mulberry leaf, ephedra, and curcumae radix, using reverse network pharmacology and cell experiments. These extracts showed no cytotoxicity on human dermal papilla cells and enhanced markers associated with hair growth, such as ALP and VEGF, while inhibiting factors like TGF-β1 and IL-6 that contribute to hair loss. The extracts also activated the Wnt/β-catenin signaling pathway, crucial for hair follicle growth. Although promising, the findings are limited to cellular observations, suggesting the need for further research. The study underscores the potential of these plant materials as safe and effective alternatives for hair loss treatment.
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      community Natural Remedies: Polyphenols and Hair Loss

       22 upvotes 6 years ago
      Natural remedies to treat hair loss, such as polyphenols, apple peel extract, grape seed extract, green tea extract, peppermint oil, pumpkin seed oil, apigenin, Ginkgo biloba, red clover extract, olive leaf extract, Ecklonia Cava and Grateloupia elliptica. In addition, terpenes, carotenoids, and tocopherols were discussed as potential treatments.

      community Take licorice to lower testosterone?

      in Question  1 upvotes 8 years ago
      Licorice is not recommended for hair loss as it inhibits hair growth and is a non-selective testosterone inhibitor. Alternatives like spironolactone are suggested for those considering hormonal treatments for hair loss.

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      in Female  6 upvotes 4 years ago
      Spudlady asks about experiences with spironolactone for hair loss. She has lost hair due to stress and seeks ways to stop shedding.

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       4 upvotes 7 years ago
      Chronic Telogen Effluvium can be managed by avoiding inflammatory foods, exercising, staying hydrated, and using supplements like krill oil, saw palmetto, or licorice root. Minoxidil is discouraged due to its cost and potential for worsening hair loss, while castor oil is recommended to strengthen hair roots and reduce shedding.

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