Polycystic Ovary Syndrome and Its Management: In View of Oxidative Stress

January 2024 in “ BioMolecular Concepts ”

Koushik Bhattacharya, Rajen Dey, Debanjana Sen, Nimisha Paul, Asim Kumar Basak, Mohuya Patra Purkait, Nandini Shukla, Gargi Ray Chaudhuri, Aniruddha Bhattacharya, Rajkumar Maiti, Krishnendu Adhikary, Prity Chatterjee, Prithviraj Karak, Alak Kumar Syamal

polycystic ovary syndrome oxidative stress insulin resistance hyperandrogenism chronic inflammation antioxidant supplements reactive oxygen species reactive nitrogen species PCOS OS

TLDR Lifestyle changes, exercise, and antioxidants can help manage polycystic ovary syndrome.

The document reviews the role of oxidative stress (OS) in polycystic ovary syndrome (PCOS) and its management. OS is linked to insulin resistance, hyperandrogenism, and chronic inflammation, which are key features of PCOS. The review suggests that lifestyle changes, including physical activity and dietary modifications, along with antioxidant supplements like vitamins E and C, alpha-lipoic acid, and other nutrients, can help manage OS and improve PCOS symptoms. It also highlights the potential benefits of medicinal herbs and the importance of understanding genetic variability in treatment responses. Overall, a multifaceted approach combining lifestyle interventions and targeted nutritional strategies is recommended for managing PCOS and its associated metabolic and hormonal imbalances.

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Research cited in this study

15 / 15 results

research Inflammatory Perspectives of Polycystic Ovary Syndrome: Role of Specific Mediators and Markers

31 citations , December 2023 in “Middle East Fertility Society Journal”

PCOS is linked to inflammation, and certain markers could help in its treatment.

research Inflammatory and Anti-Inflammatory Parameters in PCOS Patients Depending on Body Mass Index: A Case-Control Study

32 citations , October 2023 in “Biomedicines”

PCOS causes inflammation regardless of body weight.

research Vitamin B3 (Niacin), B6, C, and Iron Intake Are Associated with the Free Androgen Index, Especially in Normoandrogenic Polycystic Ovary Syndrome

10 citations , July 2022 in “Journal of the Turkish-German Gynecological Association”

Vitamins B3, B6, C, and iron intake affect hormone levels in women with certain types of PCOS.

research Insulin Resistance and Elevated Androgen Levels: A Major Cause of Polycystic Ovary Syndrome

36 citations , October 2021 in “Frontiers in Endocrinology”

Insulin resistance and high male hormone levels are major causes of Polycystic Ovary Syndrome.

research Nutrition Strategy and Lifestyle in Polycystic Ovary Syndrome: Narrative Review

49 citations , July 2021 in “Nutrients”

Eating healthy, exercising, and taking certain supplements can help manage Polycystic Ovary Syndrome symptoms.

research An Overview of Herbal Alternatives in Androgenetic Alopecia

26 citations , April 2019 in “Journal of Cosmetic Dermatology”

Herbal alternatives like saw palmetto and green tea may offer safe, effective treatment for hormonal hair loss.

research Obesity and Polycystic Ovary Syndrome: Implications for Pathogenesis and Novel Management Strategies

129 citations , January 2019 in “Clinical medicine insights”

Obesity worsens PCOS symptoms, and PCOS may lead to more weight gain; managing both requires a holistic approach that includes mental health.

research Genetic, Hormonal, and Metabolic Aspects of PCOS: An Update

258 citations , July 2016 in “Reproductive Biology and Endocrinology”

The document concludes that insulin resistance is key in PCOS development and early treatment is crucial to prevent complications.

research Protective Effects of Melatonin Against Metabolic and Reproductive Disturbances in Polycystic Ovary Syndrome in Rats

41 citations , September 2014 in “Journal of Pharmacy and Pharmacology”

Melatonin may help treat PCOS symptoms in rats.

research Polycystic Ovary Syndrome, Insulin Resistance, and Obesity: Navigating the Pathophysiologic Labyrinth

222 citations , January 2014 in “International journal of reproductive medicine”

Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

research Epidemiology, Diagnosis, and Management of Polycystic Ovary Syndrome

951 citations , December 2013 in “Clinical epidemiology”

PCOS is a common hormonal disorder in women that can be managed with lifestyle changes and various medications.

research Diagnosis and Treatment of Polycystic Ovary Syndrome: An Endocrine Society Clinical Practice Guideline

1265 citations , October 2013 in “The Journal of Clinical Endocrinology and Metabolism”

The guideline suggests using specific criteria to diagnose PCOS, recommends various treatments for its symptoms, and advises screening for related health issues.

research Mediators of Inflammation in Polycystic Ovary Syndrome in Relation to Adiposity

102 citations , January 2010 in “Mediators of Inflammation”

PCOS is linked to obesity and inflammation, increasing cardiovascular risk.

research The Androgen Excess and PCOS Society Criteria for the Polycystic Ovary Syndrome: The Complete Task Force Report

1540 citations , October 2008 in “Fertility and Sterility”

The report concludes that PCOS is mainly a condition of excess male hormones and its definition may change as new information is discovered.

research Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome

4809 citations , January 2004 in “Fertility and Sterility”

The 2003 consensus updated PCOS diagnosis criteria and highlighted increased risks of diabetes and heart disease for those affected.

Related Research

4 / 4 results

research Current Aspects of Polycystic Ovary Syndrome: A Literature Review

15 citations , December 2016 in “Revista Da Associacao Medica Brasileira”

Polycystic ovary syndrome is a common hormonal disorder in women, linked to increased risk of metabolic and heart diseases, and needs more research for better understanding and treatment.

research Polycystic Ovary Syndrome and Acne

10 citations , January 2011 in “Skin therapy letter”

Women with PCOS often have acne because of high androgen levels, and the article reviewed how to treat this type of acne.

research The Diagnosis of Polycystic Ovary Syndrome in Adolescents

212 citations , May 2010 in “American Journal of Obstetrics and Gynecology”

Diagnosing PCOS in teenagers is challenging and should use strict criteria to avoid misdiagnosis and unnecessary worry.

research Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome

4809 citations , January 2004 in “Fertility and Sterility”

The 2003 consensus updated PCOS diagnosis criteria and highlighted increased risks of diabetes and heart disease for those affected.

Polycystic Ovary Syndrome and Its Management: In View of Oxidative Stress

Research cited in this study

research Inflammatory Perspectives of Polycystic Ovary Syndrome: Role of Specific Mediators and Markers

research Inflammatory and Anti-Inflammatory Parameters in PCOS Patients Depending on Body Mass Index: A Case-Control Study

research Vitamin B3 (Niacin), B6, C, and Iron Intake Are Associated with the Free Androgen Index, Especially in Normoandrogenic Polycystic Ovary Syndrome

research Insulin Resistance and Elevated Androgen Levels: A Major Cause of Polycystic Ovary Syndrome

research Nutrition Strategy and Lifestyle in Polycystic Ovary Syndrome: Narrative Review

research An Overview of Herbal Alternatives in Androgenetic Alopecia

research Obesity and Polycystic Ovary Syndrome: Implications for Pathogenesis and Novel Management Strategies

research Genetic, Hormonal, and Metabolic Aspects of PCOS: An Update

research Protective Effects of Melatonin Against Metabolic and Reproductive Disturbances in Polycystic Ovary Syndrome in Rats

research Polycystic Ovary Syndrome, Insulin Resistance, and Obesity: Navigating the Pathophysiologic Labyrinth

research Epidemiology, Diagnosis, and Management of Polycystic Ovary Syndrome

research Diagnosis and Treatment of Polycystic Ovary Syndrome: An Endocrine Society Clinical Practice Guideline

research Mediators of Inflammation in Polycystic Ovary Syndrome in Relation to Adiposity

research The Androgen Excess and PCOS Society Criteria for the Polycystic Ovary Syndrome: The Complete Task Force Report

research Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome

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Related Research

research Current Aspects of Polycystic Ovary Syndrome: A Literature Review

research Polycystic Ovary Syndrome and Acne

research The Diagnosis of Polycystic Ovary Syndrome in Adolescents

research Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome