Protective Effects of Melatonin Against Metabolic and Reproductive Disturbances in Polycystic Ovary Syndrome in Rats

    September 2014 in “ Journal of Pharmacy and Pharmacology ”
    Sarayu Pai, Anuradha Majumdar
    Image of study
    TLDR Melatonin may help treat PCOS symptoms in rats.
    The document presents a study that explored the therapeutic effects of melatonin on polycystic ovary syndrome (PCOS) in rats. The rats with PCOS showed significant improvements when treated with melatonin at doses of 1 mg/kg and 2 mg/kg. The treatment led to reductions in body weight, BMI, intraabdominal fat, insulin levels, and C-reactive protein, as well as improved lipid profiles and glucose tolerance. Histopathological analysis revealed fewer cystic follicles and neoplastic endometrial glands, and reduced adipocyte hypertrophy. Melatonin's effects were similar to those of metformin, a common PCOS treatment. The study included six rats in the control group and eight in the treatment groups, suggesting that melatonin may be beneficial for treating PCOS, but clinical studies are needed to confirm these findings.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 251 results

      community C’est terrible - at my wits end

      in Female  443 upvotes 1 year ago
      A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.

      community Bryan Johnson just dropped his anti hair loss formula

      in Treatment  339 upvotes 9 months ago
      Bryan Johnson shared his hair loss treatment, which mainly relies on minoxidil and finasteride. Some users are skeptical of his results, while others appreciate his efforts in anti-aging and hair loss research.

      community Is anyone using melatonin for hair loss?

      in Research/Science  9 upvotes 5 months ago
      Melatonin is being discussed as a potential treatment for hair loss, with questions about its effectiveness and whether it should be used topically or orally. No specific conclusions or personal experiences were shared.

      community Melatonin options for Europe??? *Retrograde Alopecia*

      in Product  3 upvotes 6 months ago
      A user is considering using melatonin for hair recovery on the side and neck area but is unsure about the best options in Europe and whether a dietary supplement form can be applied to the scalp. They found a product but are hesitant and seeking opinions on its use for alopecia.

      community Optimal dose for topical Melatonin

      in Treatment  6 upvotes 1 year ago
      The conversation is about finding the optimal concentration of topical melatonin for hair loss treatment. The user is considering making their own solution and is unsure whether a higher concentration is more effective for deactivating prolactin receptors.

    Similar Research

    5 / 1000+ results