Effects of Melatonin Supplementation on Hormonal, Inflammatory, Genetic, and Oxidative Stress Parameters in Women With Polycystic Ovary Syndrome

    May 2019 in “ Frontiers in Endocrinology ”
    Mehri Jamilian, Fatemeh Foroozanfard, Naghmeh Mirhosseini, Elham Kavossian, Esmat Aghadavod, Fereshteh Bahmani, Vahidreza Ostadmohammadi, Mersedeh Kia, Tahereh Eftekhar, Elnaz Ayati, Mostafa Mahdavinia, Zatollah Asemi
    TLDR Melatonin may improve some hormonal and inflammatory issues in women with PCOS.
    This study examined the impact of melatonin supplementation on 56 women with polycystic ovary syndrome (PCOS) undergoing IVF over 12 weeks. Melatonin significantly reduced hirsutism, serum total testosterone, hs-CRP, and plasma MDA levels, while increasing plasma TAC and GSH levels. It also downregulated the gene expression of inflammatory markers IL-1 and TNF-α, indicating an anti-inflammatory effect. However, melatonin did not affect plasma nitric oxide or serum SHBG levels. These findings suggested that melatonin could improve certain hormonal and inflammatory profiles in women with PCOS, although the study was limited by the inability to measure serum melatonin levels and assess other biomarkers.
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