Inflammatory Perspectives of Polycystic Ovary Syndrome: Role of Specific Mediators and Markers

    December 2023 in “ Middle East Fertility Society Journal ”
    Rajen Dey, Koushik Bhattacharya, Asim Kumar Basak, Nimisha Paul, Raktima Bandyopadhyay, Gargi Ray Chaudhuri, Mahuya Patra Purkait, Aniruddha Bhattacharjee, Chaitali Bose, Nandini Shukla, Rama Bhaduri, Soumya Sinha Roy, Alak Kumar Syamal
    Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder in women of reproductive age, with its relationship to low-grade chronic inflammation being complex and not fully understood. This review highlights the association between PCOS and various inflammatory markers such as IL-6, TNF-α, IL-17, CRP, NLR, and PLR. Increased levels of IL-17, IL-1, and IL-8 are linked to PCOS, and the CRP to albumin ratio is suggested as a precise biomarker for the condition. The neutrophil-to-lymphocyte ratio (NLR) is associated with poor cardiovascular health and metabolic syndrome, potentially influencing testosterone production. Additionally, the platelet/lymphocyte ratio (PLR) and mean platelet volume (MPV) are newly associated with PCOS. Understanding these inflammatory markers' roles could lead to new treatment approaches for PCOS.
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