Inflammatory Perspectives of Polycystic Ovary Syndrome: Role of Specific Mediators and Markers

    December 2023 in “ Middle East Fertility Society Journal ”
    Rajen Dey, Koushik Bhattacharya, Asim Kumar Basak, Nimisha Paul, Raktima Bandyopadhyay, Gargi Ray Chaudhuri, Mahuya Patra Purkait, Aniruddha Bhattacharjee, Chaitali Bose, Nandini Shukla, Rama Bhaduri, Soumya Sinha Roy, Alak Kumar Syamal
    TLDR PCOS is linked to inflammation, and certain markers could help in its treatment.
    This review discusses the role of inflammation in polycystic ovary syndrome (PCOS), highlighting specific inflammatory markers such as IL-6, TNF-α, IL-17, CRP, NLR, and PLR. These markers are linked to chronic inflammation, insulin resistance, and hyperandrogenism in PCOS. The document suggests that inflammation in adipose tissue, driven by hypertrophic adipocytes and immune cells, may significantly contribute to PCOS development. Elevated levels of these markers indicate a state of low-grade chronic inflammation, which can exacerbate metabolic and cardiovascular issues. The review calls for further research to explore the interactions between hyperandrogenism, adipose tissue inflammation, and the genetic factors involved in PCOS, aiming to improve diagnosis, prognosis, and treatment strategies.
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