Inflammatory Perspectives of Polycystic Ovary Syndrome: Role of Specific Mediators and Markers

December 2023 in “ Middle East Fertility Society Journal ”

Rajen Dey, Koushik Bhattacharya, Asim Kumar Basak, Nimisha Paul, Raktima Bandyopadhyay, Gargi Ray Chaudhuri, Mahuya Patra Purkait, Aniruddha Bhattacharjee, Chaitali Bose, Nandini Shukla, Rama Bhaduri, Soumya Sinha Roy, Alak Kumar Syamal

polycystic ovary syndrome PCOS IL-6 TNF-α IL-17 CRP NLR PLR IL-1 IL-8 CRP to albumin ratio neutrophil-to-lymphocyte ratio testosterone platelet/lymphocyte ratio mean platelet volume C-reactive protein

TLDR PCOS is linked to inflammation, and certain markers could help in its treatment.

This review discusses the role of inflammation in polycystic ovary syndrome (PCOS), highlighting specific inflammatory markers such as IL-6, TNF-α, IL-17, CRP, NLR, and PLR. These markers are linked to chronic inflammation, insulin resistance, and hyperandrogenism in PCOS. The document suggests that inflammation in adipose tissue, driven by hypertrophic adipocytes and immune cells, may significantly contribute to PCOS development. Elevated levels of these markers indicate a state of low-grade chronic inflammation, which can exacerbate metabolic and cardiovascular issues. The review calls for further research to explore the interactions between hyperandrogenism, adipose tissue inflammation, and the genetic factors involved in PCOS, aiming to improve diagnosis, prognosis, and treatment strategies.

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Research cited in this study

8 / 8 results

research Polycystic Ovary Syndrome (PCOS): An Inflammatory, Systemic, Lifestyle Endocrinopathy

317 citations , April 2018 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

PCOS is a complex condition in women that can lead to health issues, and lifestyle changes are the best management approach.

research Tumor Necrosis Factor-Alpha and Polycystic Ovarian Syndrome: A Clinical, Biochemical, and Molecular Genetic Study

26 citations , August 2014 in “Genetic Testing and Molecular Biomarkers”

High levels of TNF-α may contribute to obesity and insulin resistance in PCOS, but not due to the C850T genetic variation.

research Polycystic Ovary Syndrome, Insulin Resistance, and Obesity: Navigating the Pathophysiologic Labyrinth

222 citations , January 2014 in “International journal of reproductive medicine”

Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

research The Androgen Excess and PCOS Society Criteria for the Polycystic Ovary Syndrome: The Complete Task Force Report

1540 citations , October 2008 in “Fertility and Sterility”

The report concludes that PCOS is mainly a condition of excess male hormones and its definition may change as new information is discovered.

research Abdominal Fat Quantity and Distribution in Women with Polycystic Ovary Syndrome and Its Relation to Insulin Resistance

270 citations , April 2007 in “The Journal of Clinical Endocrinology and Metabolism”

Women with PCOS often have more belly fat and higher insulin levels, but belly fat isn't the only cause of their insulin resistance.

Criteria for Defining Polycystic Ovary Syndrome as a Predominantly Hyperandrogenic Syndrome: An Androgen Excess Society Guideline

research Criteria for Defining Polycystic Ovary Syndrome as a Predominantly Hyperandrogenic Syndrome: An Androgen Excess Society Guideline

1744 citations , August 2006 in “The Journal of Clinical Endocrinology and Metabolism”

Polycystic Ovary Syndrome should be seen mainly as a condition of excess male hormones, with a focus on this in its definition.

research Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome

4809 citations , January 2004 in “Fertility and Sterility”

The 2003 consensus updated PCOS diagnosis criteria and highlighted increased risks of diabetes and heart disease for those affected.

A Prospective Study of the Prevalence of Clear-Cut Endocrine Disorders and Polycystic Ovaries in 350 Patients Presenting with Hirsutism or Androgenic Alopecia

research A Prospective Study of the Prevalence of Clear-Cut Endocrine Disorders and Polycystic Ovaries in 350 Patients Presenting with Hirsutism or Androgenic Alopecia

135 citations , August 1994 in “Clinical Endocrinology”

Most women with hirsutism or androgenic alopecia had polycystic ovaries, especially if they had irregular periods.

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Inflammatory Perspectives of Polycystic Ovary Syndrome: Role of Specific Mediators and Markers

Research cited in this study

research Polycystic Ovary Syndrome (PCOS): An Inflammatory, Systemic, Lifestyle Endocrinopathy

research Tumor Necrosis Factor-Alpha and Polycystic Ovarian Syndrome: A Clinical, Biochemical, and Molecular Genetic Study

research Polycystic Ovary Syndrome, Insulin Resistance, and Obesity: Navigating the Pathophysiologic Labyrinth

research The Androgen Excess and PCOS Society Criteria for the Polycystic Ovary Syndrome: The Complete Task Force Report

research Abdominal Fat Quantity and Distribution in Women with Polycystic Ovary Syndrome and Its Relation to Insulin Resistance

research Criteria for Defining Polycystic Ovary Syndrome as a Predominantly Hyperandrogenic Syndrome: An Androgen Excess Society Guideline

research Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome

research A Prospective Study of the Prevalence of Clear-Cut Endocrine Disorders and Polycystic Ovaries in 350 Patients Presenting with Hirsutism or Androgenic Alopecia

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