A Prospective Study of the Prevalence of Clear-Cut Endocrine Disorders and Polycystic Ovaries in 350 Patients Presenting with Hirsutism or Androgenic Alopecia

    August 1994 in “ Clinical Endocrinology ”
    J. B. O'Driscoll, Hari Mamtora, John Higginson, A. M. T. Pollock, John M. Kane, Dana Z. Anderson
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    TLDR Most women with hirsutism or androgenic alopecia had polycystic ovaries, especially if they had irregular periods.
    In 1994, a study involving 350 women with hirsutism and/or androgenic alopecia assessed the prevalence of polycystic ovaries (PCO) and clear-cut endocrine disorders. The study revealed that 8 women had significant endocrine disorders, while PCO was found in 81% of women with erratic menstrual cycles and 52% with regular cycles. The study highlighted the utility of high-resolution ultrasound for PCO detection and the association of PCO with insulin resistance and increased coronary artery disease risk. It recommended that a single serum testosterone measurement be included in routine assessments for such patients, and if levels exceed 5 nmol/l, a comprehensive endocrine evaluation should be conducted. This evaluation should include repeated hormone measurements and relevant tests, particularly if there is a history of amenorrhea.
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