Systematic Review: The Platelet-Rich Plasma Use in Female Androgenetic Alopecia as Effective Autologous Treatment of Regenerative Plastic Surgery

November 2021 in “ Journal of Plastic Reconstructive and Aesthetic Surgery ”

Pietro Gentile, Simone Garcovich

platelet-rich plasma female androgenetic alopecia PRP Minoxidil Finasteride Rogaine Propecia

TLDR Platelet-rich plasma is a safe and effective treatment for female hair loss.

This systematic review evaluated the safety and efficacy of platelet-rich plasma (PRP) for treating female androgenetic alopecia (F-AGA). Out of 63 initially identified articles, 5 focused exclusively on F-AGA, including 3 randomized-controlled trials, 1 clinical trial, and 1 double-blind placebo-controlled pilot study. The review found that PRP had positive effects on F-AGA without major side effects, suggesting it as a safe and effective alternative to traditional treatments like Minoxidil® and Finasteride®.

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Research cited in this study

18 / 18 results

A Randomized Blinded Retrospective Study: The Combined Use of Micro-Needling Technique, Low-Level Laser Therapy, and Autologous Non-Activated Platelet-Rich Plasma Improves Hair Re-Growth in Patients with Androgenic Alopecia

research A Randomized Blinded Retrospective Study: The Combined Use of Micro-Needling Technique, Low-Level Laser Therapy, and Autologous Non-Activated Platelet-Rich Plasma Improves Hair Re-Growth in Patients with Androgenic Alopecia

20 citations, July 2020 in “Expert Opinion on Biological Therapy”

Using micro-needling, low-level laser therapy, and platelet-rich plasma together significantly improves hair growth in people with hair loss.

research The Effect of Platelet-Rich Plasma on Female Androgenetic Alopecia: A Randomized Controlled Trial

18 citations, July 2020 in “Journal of The American Academy of Dermatology”

PRP injections improve hair density and thickness in women with hair loss.

Systematic Review of Platelet-Rich Plasma Use in Androgenetic Alopecia Compared with Minoxidil, Finasteride, and Adult Stem Cell-Based Therapy

research Systematic Review of Platelet-Rich Plasma Use in Androgenetic Alopecia Compared with Minoxidil, Finasteride, and Adult Stem Cell-Based Therapy

65 citations, April 2020 in “International Journal of Molecular Sciences”

PRP injections may be a safe, effective alternative for hair loss treatment compared to minoxidil and finasteride.

Impact of Different Preparation Methods to Obtain Autologous Non-Activated Platelet-Rich Plasma and Activated Platelet-Rich Plasma in Plastic Surgery: Wound Healing and Hair Regrowth Evaluation

research Impact of Different Preparation Methods to Obtain Autologous Non-Activated Platelet-Rich Plasma and Activated Platelet-Rich Plasma in Plastic Surgery: Wound Healing and Hair Regrowth Evaluation

58 citations, January 2020 in “International Journal of Molecular Sciences”

Different methods of preparing Platelet-Rich Plasma (PRP) can affect wound healing and hair regrowth in plastic surgery. Using a kit with specific standards helps isolate PRP that meets quality criteria. Non-Activated PRP and Activated PRP have varying effects depending on the tissue and condition treated. For hair regrowth, Non-Activated PRP increased hair density more than Activated PRP. Both treatments improved various aspects of scalp health.

A Randomized, Controlled Pilot Trial Comparing Platelet-Rich Plasma to Topical Minoxidil Foam for Treatment of Androgenic Alopecia in Women

research A Randomized, Controlled Pilot Trial Comparing Platelet-Rich Plasma to Topical Minoxidil Foam for Treatment of Androgenic Alopecia in Women

22 citations, October 2019 in “Dermatologic Surgery”

Both Platelet-Rich Plasma and Minoxidil foam increase hair count in women with hair loss, but Minoxidil is more effective. However, women were more satisfied with Platelet-Rich Plasma treatment.

research Autologous Cellular Method Using Micrografts of Human Adipose Tissue Derived Follicle Stem Cells in Androgenic Alopecia

88 citations, July 2019 in “International Journal of Molecular Sciences”

Using human fat tissue derived stem cells in micrografts can safely and effectively increase hair density in people with hair loss.

Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

research Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

136 citations, May 2019 in “Cells”

Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.

Investigation of the Development of Hypersensitivity and Hyperalgesia After Repeated Application of Platelet-Rich Plasma in Rats: An Experimental Study

research Investigation of the Development of Hypersensitivity and Hyperalgesia After Repeated Application of Platelet-Rich Plasma in Rats: An Experimental Study

7 citations, April 2019 in “Aesthetic Surgery Journal”

Repeated use of platelet-rich plasma in rats caused increased pain sensitivity.

Platelet-Rich Plasma and Micrografts Enriched with Autologous Human Follicle Mesenchymal Stem Cells Improve Hair Regrowth in Androgenetic Alopecia: Biomolecular Pathway Analysis and Clinical Evaluation

research Platelet-Rich Plasma and Micrografts Enriched with Autologous Human Follicle Mesenchymal Stem Cells Improve Hair Regrowth in Androgenetic Alopecia: Biomolecular Pathway Analysis and Clinical Evaluation

69 citations, April 2019 in “Biomedicines”

PRP and HF-MSCs treatment improves hair growth, thickness, and density in androgenetic alopecia.

research Platelet-Rich Plasma on Female Androgenetic Alopecia: Tested on 10 Patients

25 citations, April 2018 in “Journal of Cosmetic Dermatology”

PRP injections increase hair density and diameter in female androgenetic alopecia patients.

The Effect of Autologous Activated Platelet-Rich Plasma Injection on Female Pattern Hair Loss: A Randomized Placebo-Controlled Study

research The Effect of Autologous Activated Platelet-Rich Plasma Injection on Female Pattern Hair Loss: A Randomized Placebo-Controlled Study

52 citations, May 2017 in “Journal of Cosmetic Dermatology”

PRP injections improve hair density and thickness in women with hair loss.

Evaluation of Non-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems

research Evaluation of Non-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems

136 citations, February 2017 in “International Journal of Molecular Sciences”

PRP treatment improves hair growth, and the device used can affect results, with some being more effective.

research Double-Blind, Placebo-Controlled Pilot Study on the Use of Platelet-Rich Plasma in Women With Female Androgenetic Alopecia

87 citations, September 2016 in “Dermatologic Surgery”

PRP shows potential for treating female hair loss, but more research needed.

research The Effect of Platelet-Rich Plasma in Hair Regrowth: A Randomized Placebo-Controlled Trial

214 citations, September 2015 in “Stem Cells Translational Medicine”

Platelet-rich plasma injections significantly improved hair regrowth and thickness in patients with hair loss.

Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells

research Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells

235 citations, January 2011 in “Journal of Clinical Investigation”

Men with baldness due to androgenetic alopecia still have hair stem cells, but lack specific cells needed for hair growth.

research Androgens and Hair Loss: An In-Depth Analysis of Androgenetic Alopecia

52 citations, June 2009 in “Current Opinion in Endocrinology, Diabetes and Obesity”

The document concludes that hair transplantation and gene therapy may be important for future hair loss treatment.

research Treatment of Hair Loss

370 citations, September 1999 in “The New England Journal of Medicine”

Finasteride and minoxidil are effective for hair loss, but continued research is needed for better treatments.

research The Biology of Hair Follicles

1113 citations, August 1999 in “The New England Journal of Medicine”

Hair follicle biology advancements may lead to better hair growth disorder treatments.

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research Treatment of Androgenetic Alopecia Using PRP to Target Dysregulated Mechanisms and Pathways

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research Platelet-Rich Plasma and Stem Cells for Hair Growth: A Review of the Literature

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Platelet-Rich Plasma and stem cell therapy can increase hair count and density, but the best method for preparation and treatment still needs to be determined.

research Effectiveness of Platelet-Rich Plasma Therapy in Androgenic Alopecia: A Meta-Analysis

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research The Efficacy of Platelet-Rich Plasma in Hair Restoration and Facial Aesthetics: A Systematic Review and Meta-Analysis

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Platelet-Rich Plasma (PRP) therapy can promote hair growth and improve facial aesthetics, including reducing acne scars and facial burns, and it works best with three initial monthly injections.

research Androgenetic Alopecia: Use of Platelet-Rich Plasma and Low-Level Laser Therapy

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PRP and LLLT can improve hair growth in AGA, but more research needed.

research Platelet-Rich Plasma for Hair Restoration

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Platelet-Rich Plasma (PRP), a substance from a patient's own blood, can stimulate hair regrowth in people with Androgenetic Alopecia (AGA) who haven't had success with other treatments, but more research is needed to optimize its use.