Investigation of the Development of Hypersensitivity and Hyperalgesia After Repeated Application of Platelet-Rich Plasma in Rats: An Experimental Study

    April 2019 in “ Aesthetic Surgery Journal ”
    Bilsev İnce, Mehmet Yıldırım, İbrahim Kılınç, Pembe Oltulu, Mehmet Dadacı
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    TLDR Repeated use of platelet-rich plasma in rats caused increased pain sensitivity.
    In a 2019 study involving 32 rats, researchers found that repeated applications of both nonactivated and activated platelet-rich plasma (PRP) resulted in the development of hyperalgesia, or hypersensitivity to pain. This was indicated by smaller Von Frey g values, suggesting greater hypersensitivity, in areas treated with PRP compared to those treated with saline or no treatment. Additionally, nerve growth factor (NGF) levels were higher in PRP-treated areas, suggesting that the development of hyperalgesia may be associated with an increase in NGF and increased inflammatory mediators. The study concluded that repeated PRP treatment may lead to hyperalgesia.
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      in Treatment  3 upvotes 1 month ago
      Platelet-rich plasma (PRP) therapy for hair loss is expensive, painful, and often ineffective, with mixed reviews on its benefits. Alternatives like minoxidil, finasteride, and hair transplants are suggested as more reliable options.

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      in Treatment  5 upvotes 8 months ago
      A 27-year-old male experienced rapid hair loss after dengue fever, which activated a balding gene. The doctor suggested platelet-rich plasma treatment for hair regrowth.

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      in Treatment  3 upvotes 2 years ago
      Hair loss discussion includes treatments like Minoxidil, finasteride, and RU58841. Platelet rich plasma treatment is considered expensive but cheaper than hair transplant.

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      in Treatment  1 upvotes 1 year ago
      A 27-year-old male experiencing hair loss post-Covid is considering PRP (platelet-rich plasma) therapy. He's seeking personal experiences about the process, particularly regarding pain levels, despite his dermatologist's assurance of using local anesthesia.

      community Do Platelet-rich plasma, PRP work?

      in Research/Science  13 upvotes 1 year ago
      Someone's brother tried Platelet-rich plasma (PRP) for hair loss; it had minimal effect on hair but improved skin appearance. Microneedling at home was suggested as a more sustainable alternative.

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