Immunohistochemical, Pharmacovigilance, and Omics Analyses Reveal the Involvement of ATP-Sensitive K+ Channel Subunits in Cancers: Role in Drug-Disease Interactions

April 2023 in “ Frontiers in Pharmacology ”

Fatima Maqoud, Nicola Zizzo, Marcella Attimonelli, Andrea Tinelli, Giuseppe Passantino, Marina Antonacci, Girolamo Ranieri, Domenico Tricarico

ATP-sensitive potassium channels KATP channels Sur2A subunit Kir6.1 Kir6.2 minoxidil renal cancer breast cancer mammary neoplasia cell proliferation Rogaine

TLDR ATP-sensitive K+ channel subunits, particularly Sur2A, play a significant role in various cancers.

The document investigates the role of ATP-sensitive potassium (KATP) channels, specifically the Sur2A subunit and its accessory subunits Kir6.1 and/or Kir6.2, in various diseases including cancers. The study used immunohistochemical markers to analyze kidney cancer in rats and mammary neoplasia in 23 female dogs. It found that long-term topical treatment with high doses of minoxidil induced cell proliferation and cancer in male rats. The Sur2A subunit showed a marked elevation in renal cancer cells in male rats and in G3 cells of canine breast cancer. The study also found that minoxidil-induced upregulation of the KATP channels can be associated with high cancer risk in some common cancers including breast cancer in humans but not pancreatic cancer. The document concludes that the Sur2A subunit of ATP-sensitive K+ channels plays a significant role in various types of cancers.

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Research cited in this study

research Repurposing Kir6/SUR2 Channel Activator Minoxidil to Arrest Growth of Gynecologic Cancers

research The Hydroxypropyl-β-Cyclodextrin-Minoxidil Inclusion Complex Improves the Cardiovascular and Proliferative Adverse Effects of Minoxidil in Male Rats: Implications in the Treatment of Alopecia

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research Cantú Syndrome with Coexisting Familial Pituitary Adenoma

research Characterization of Minoxidil/Hydroxypropyl-β-Cyclodextrin Inclusion Complex in Aqueous Alginate Gel Useful for Alopecia Management: Efficacy Evaluation in Male Rats

research Minoxidil May Suppress Androgen Receptor-Related Functions

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