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    Immunohistochemical, Pharmacovigilance, and Omics Analyses Reveal the Involvement of ATP-Sensitive K+ Channel Subunits in Cancers: Role in Drug-Disease Interactions

    April 2023 in “ Frontiers in Pharmacology ”
    Fatima Maqoud, Nicola Zizzo, Marcella Attimonelli … Domenico Tricarico
    Studysummary This study identified high expression of the Sur2A subunit in cancerous cells in two animal models, highlighting a potential drug target in breast and renal cancers, with additional pharmacovigilance data linking KATP channel genes to varied cancer risks.
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    Research cited in this study 9

    1. Repurposing Kir6/SUR2 Channel Activator Minoxidil to Arrest Growth of Gynecologic Cancers Frontiers in pharmacology · 2020
    2. The Hydroxypropyl-β-Cyclodextrin-Minoxidil Inclusion Complex Improves the Cardiovascular and Proliferative Adverse Effects of Minoxidil in Male Rats: Implications in the Treatment of Alopecia Pharmacology Research & Perspectives · 2020
    3. New Drugs Under Investigation for the Treatment of Alopecias Expert Opinion on Investigational Drugs · 2019
    4. Cantú Syndrome with Coexisting Familial Pituitary Adenoma Endocrine · 2018
    5. Characterization of Minoxidil/Hydroxypropyl-β-Cyclodextrin Inclusion Complex in Aqueous Alginate Gel Useful for Alopecia Management: Efficacy Evaluation in Male Rats European Journal of Pharmaceutics and Biopharmaceutics · 2017
    6. Minoxidil May Suppress Androgen Receptor-Related Functions Oncotarget · 2014
    7. K ATP Channels and Cardiovascular Disease Circulation Research · 2013
    8. Glibenclamide Inhibits Cell Growth by Inducing G0/G1 Arrest in the Human Breast Cancer Cell Line MDA-MB-231 BMC Pharmacology and Toxicology · 2013
    9. Human Hair Follicles Contain Two Forms of ATP-Sensitive Potassium Channels, Only One Sensitive to Minoxidil The FASEB Journal · 2008