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GlossaryATP-sensitive potassium channels (KATP channels)

regulate potassium ion flow based on cellular energy levels

ATP-sensitive potassium channels (KATP channels) are specialized proteins found in the cell membrane that help regulate the flow of potassium ions in and out of the cell. These channels are sensitive to the levels of ATP (adenosine triphosphate), the cell's main energy currency, and they open or close in response to changes in ATP concentration. This mechanism allows the channels to play a crucial role in linking the cell's metabolic state to its electrical activity, which is important in various physiological processes such as insulin release, muscle contraction, and neuronal activity.

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research Combination Therapy Profoundly Improved Skin Flap Survival by Modulating KATP Channels and Nitric Oxide

1 citations, January 2019 in “Advances in Medical Sciences”

The combination of azelaic acid, minoxidil, and caffeine significantly increased the survival of skin flaps by affecting certain body channels and nitric oxide levels.

research The Possible Involvement of KATP Channels in Cholestatic Pruritus in Mice

July 2024 in “Research Square (Research Square)”

KATP channels may help reduce itching in liver disease.

research KATP Channels in Zebrafish Cardiovascular System: A Model to Study Cantú Syndrome

February 2020 in “Biophysical journal”

Zebrafish with mutations similar to human Cantú Syndrome have heart cells with altered channel properties, making them a good model to study the condition.

research The Emerging Structural Pharmacology of ATP-Sensitive Potassium Channels

5 citations, September 2022 in “Molecular pharmacology”

KATP channels are important for energy balance and are targeted by drugs for diabetes, hypoglycemia, hypertension, and hair loss.

research Minoxidil Opens Mitochondrial KATP Channels and Confers Cardioprotection

28 citations, January 2004 in “British Journal of Pharmacology”

Minoxidil protects heart and improves recovery.

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community Update of my case, might have finally found what happened

in Minoxidil 6 upvotes 3 months ago

OP believes RU58841 affected their thyroid, causing hypothyroidism and impacting minoxidil's effectiveness. They plan to start thyroid medication to improve hair regrowth.

community KX-826: Long-Term Safety Results are out!

in Research/Science 156 upvotes 2 months ago

KX-826 initially improves hair growth but declines after 24 weeks, with mild itching as a side effect. Combining it with minoxidil and finasteride may improve results, but long-term effectiveness is uncertain.