The Emerging Structural Pharmacology of ATP-Sensitive Potassium Channels

September 2022 in “ Molecular pharmacology ”

Jing-Xiang Wu, Dian Ding, Lei Chen

ATP-sensitive potassium channels KATP KATP inhibitors KATP activators sulfonylurea receptor SUR nucleotide-binding domains NBDs

Studysummary This article reviews current knowledge on KATP channel drug binding modes through cryogenic electron microscopy, highlighting distinct binding sites in the sulfonylurea receptor and potential mechanisms of drug action, but reports no new experimental results.

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