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Glossary Breast Cancer

malignancy originating in breast tissue cells

Breast cancer, also known as breast carcinoma, is a type of malignancy that originates in the cells of the breast tissue. It can develop in the ducts (ductal carcinoma) or lobules (lobular carcinoma) and may spread to other parts of the body if not detected and treated early. Early detection through screening methods like mammograms significantly improves the prognosis.

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Research

5 / 1000+ results

research Revising the role of the androgen receptor in breast cancer

68 citations , April 2014 in “Journal of Molecular Endocrinology”

This review summarizes existing knowledge on androgen receptor activity in breast cancer and reports no new clinical findings, with emphasis on therapies targeting androgen signaling in specific BC subtypes.

research Vitamin D and androgen receptor-targeted therapy for triple-negative breast cancer

59 citations , April 2016 in “Breast Cancer Research and Treatment”

This study found that AR/VDR-targeted agonist hormone therapy can inhibit cell viability in HR2-av triple-negative breast cancer cell lines through multiple mechanisms and may enhance the effects of chemotherapy.

research Matriptase activation and shedding with HAI-1 is induced by steroid sex hormones in human prostate cancer cells, but not in breast cancer cells

56 citations , February 2006 in “American journal of physiology. Cell physiology”

This study observed that in hormone-starved prostate cancer cells, the androgen 5alpha-dihydrotestosterone rapidly induces matriptase activation and shedding, which involves androgen receptor signaling and requires both transcription and protein synthesis.

research Aromatase inhibitor therapy and hair loss among breast cancer survivors

34 citations , November 2013 in “Breast Cancer Research and Treatment”

This study found that female breast cancer survivors using aromatase inhibitors were observed to have a higher likelihood of experiencing hair loss and thinning compared to those not treated with these drugs.

research A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients

32 citations , September 2013 in “Breast cancer research”

This study identified a specific SNP in the CACNB4 gene associated with a higher risk of chemotherapy-induced alopecia in breast cancer patients, which may help develop interventions to improve their quality of life.

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Community Join

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community Dermatologist refused to prescribe finasteride due to “new research” on male breast cancer. anyone heard of this?

in Research/Science 54 upvotes 9 months ago

A dermatologist refused to prescribe finasteride due to concerns about recent research linking it to male breast cancer, suggesting a topical alternative with minoxidil instead. The user is advised to seek a second opinion, as the evidence for such risks is inconclusive and the dermatologist's reasoning seems questionable.

community Experiencing Breast Tenderness on 3 Weeks Oral Fin, Will It Improve?

in Finasteride 67 upvotes 1 year ago

The user is experiencing breast tenderness and lumps after three weeks on 0.5 mg oral finasteride, a common side effect. They also report mild brain fog and fatigue but are less concerned about these symptoms.

community My mother has been losing hair as of recently (she's approaching 60). What are the best supplements and medications I could buy for her to help her with thinning hair, apart from high quality multivitamin, collagen with hyaluronic acid, omega-3s and other basics?

2 upvotes 2 years ago

A user seeks advice on treatments for his mother's hair loss, considering Minoxidil, Finasteride, and shampoos. The mother is being monitored for breast cancer, which may be relevant.

community Twist-1 vs Scube-3. Is it worth pursuing both?

15 upvotes 4 years ago

Twist-1 is being explored as a promising early-stage hair loss treatment, while Scube-3's effect on Twist-1 in breast cancer cells raises concerns about its use for hair loss. The conversation discusses the potential differences in protein effects across various cell types.

community Serenoa repens (Saw palmetto)

3 upvotes 7 months ago

Saw palmetto, a 5-alpha reductase inhibitor, caused unexpected side effects like breast changes and altered semen consistency, which resolved after stopping its use. Concerns about similar side effects with finasteride or dutasteride were expressed, and another user reported low libido and depression from saw palmetto.

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Learn

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learn Bicalutamide

Nonsteroidal anti-androgen, originally a prostate cancer drug

learn Dutasteride

Is it dangerous to buy dutasteride without a prescription? Dutasteride is a prescription medicine, and its US label warns about a PSA drop, a higher rate of high-grade prostate cancer in one trial, sexual and breast side effects (the sexual ones may persist after stopping, with dutasteride's role unknown), depressed mood and a new UK class warning about depression and suicidal thoughts, risks in pregnancy and a 6-month blood-donation deferral. Buying from unregulated online sellers adds the risk of counterfeit or contaminated products.

learn Estradiol

Estrogen hormone, prescribed in tablet, patch and gel forms

learn Stem Cell Factor

learn Cyproterone

a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

learn Finasteride

Popular 5-alpha reductase inhibitor that lowers DHT, taken as a pill or used topically

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Clinics

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