Applications of Marine Organism-Derived Polydeoxyribonucleotide: Its Potential in Biomedical Engineering

The document reviews the therapeutic applications of Polydeoxyribonucleotide (PDRN), a DNA-derived drug extracted from salmon trout or chum salmon sperm cells, and its potential in biomedical engineering. PDRN has been found to have wound healing, anti-inflammatory, and other therapeutic properties, such as promoting osteoblast activity, collagen synthesis, and angiogenesis, primarily through the activation of the adenosine A2A receptor and salvage pathways. The review analyzed 70 studies, indicating a growing interest in PDRN research, with most studies focusing on in vivo models and clinical studies related to wound healing and anti-inflammatory effects. PDRN has shown promise in treating various diseases and conditions, including postoperative cognitive dysfunction, ischemic colitis, inflammatory bowel disease, lung injury, osteonecrosis, and tissue injury. It has also been effective in regenerating bone tissue, torn tendons, and improving surgical outcomes such as scar formation and rhinoplasty results. PDRN has been combined with other treatments like thulium laser therapy for hair loss, showing improvements in hair thickness and count. Despite its potential, the review highlights the need for further research to fully understand PDRN's biological activities, mechanisms, and to develop more cost-effective extraction sources and administration strategies.