TLDR Classic PDRN improves wound healing quality by enhancing cell migration.
The study investigated the effects of different molecular weights of polydeoxyribonucleotides (PDRNs) on wound healing in a mouse model and found that classic PDRN (50-1,500 kDa) significantly improved the quality of wound healing. While surface wound closure did not differ significantly among the PDRNs, classic PDRN-treated mice exhibited less lipid accumulation and increased collagen composition, indicating enhanced healing quality. Classic PDRN also promoted cell migration via c-Jun N-terminal kinase signaling in human fibroblasts, suggesting its potential as a therapeutic agent for tissue regeneration by improving wound healing processes through enhanced cell migration rather than proliferation.
80 citations
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April 2017 in “Frontiers in Pharmacology” PDRN helps repair tissue and improve wound healing with a high safety profile.
18 citations
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September 2016 in “International Journal of Molecular Sciences” Polydeoxyribonucleotide (PDRN) may help lighten skin and treat hyperpigmentation.
54 citations
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December 2014 in “Wound Repair and Regeneration” PRP injections may improve hair thickness and density in female hair loss patients.
April 2025 in “Journal of Skin and Stem Cell” PDRN from trout sperm helps skin and hair regeneration but is costly and complex to produce.
14 citations
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May 2021 in “Marine Drugs” PDRN, derived from salmon sperm, shows promise in healing wounds, reducing inflammation, and regenerating tissues, but more research is needed to understand its mechanisms and improve its use.
18 citations
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September 2016 in “International Journal of Molecular Sciences” Polydeoxyribonucleotide (PDRN) may help lighten skin and treat hyperpigmentation.
17 citations
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October 2023 in “Molecules” Plant-derived PDRN from ginseng roots effectively heals skin and improves its barrier.
June 2019 in “Journal of Dermatological Treatment” BM-PHA is as effective and safe as Restylane Perlane for improving nasolabial folds with minor side effects.
