Polydeoxyribonucleotide in Skincare and Cosmetics: Mechanisms, Therapeutic Applications, and Advancements Beyond Wound Healing and Anti-Aging

Polydeoxyribonucleotide (PDRN), derived from trout sperm, is gaining attention in skincare and cosmetics for its regenerative properties, particularly in anti-aging, wound healing, and hair loss treatments. It stimulates collagen production, angiogenesis, and reduces inflammation, making it effective in treating acne scars and inhibiting melanogenesis. PDRN activates purinergic receptors, promoting tissue repair and regeneration, and shows promise in hair regrowth, especially when combined with platelet-rich plasma (PRP), improving hair count and thickness in female pattern hair loss patients. Despite its potential, PDRN's clinical application is limited by high costs and complex production, necessitating further research to optimize treatment protocols and explore cost-effective production methods.