Polydeoxyribonucleotide in Skincare and Cosmetics: Mechanisms, Therapeutic Applications, and Advancements Beyond Wound Healing and Anti-Aging

April 2025 in “ Journal of Skin and Stem Cell ”

Seyedeh Melika Akaberi, Kavita Sharma, Hamid Reza Ahmadi-Ashtiani, Mehdi Hedayati

polydeoxyribonucleotide PDRN collagen production angiogenesis inflammation reduction melanogenesis inhibition purinergic receptors tissue repair hair regrowth platelet-rich plasma PRP female pattern hair loss collagen inflammation hair growth hair loss

From the encyclopedia

Platelet-Rich Plasma →

growth factors taken from your blood and injected into your scalp to stimulate hair

collagen →

Studysummary This review discusses the potential of polydeoxyribonucleotide (PDRN) for various dermatological treatments and highlights its significant effects on wound healing, anti-aging, acne scars, and hair loss, but emphasizes the need for further clinical studies. Our plain-language summary of this paper — not a Tressless recommendation.

Polydeoxyribonucleotide (PDRN), derived from trout sperm, is gaining attention in skincare and cosmetics for its regenerative properties, particularly in anti-aging, wound healing, and hair loss treatments. It stimulates collagen production, angiogenesis, and reduces inflammation, making it effective in treating acne scars and inhibiting melanogenesis. PDRN activates purinergic receptors, promoting tissue repair and regeneration, and shows promise in hair regrowth, especially when combined with platelet-rich plasma (PRP), improving hair count and thickness in female pattern hair loss patients. Despite its potential, PDRN's clinical application is limited by high costs and complex production, necessitating further research to optimize treatment protocols and explore cost-effective production methods.

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Research cited in this study

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research An Effective Range of Polydeoxyribonucleotides Is Critical for Wound Healing Quality

22 citations , October 2018 in “Molecular Medicine Reports”

In this study, classic PDRN (50-1,500 kDa) was observed to improve wound healing quality in a mouse model by enhancing collagen composition and cell migration.

research Novel Anti-Melanogenesis Properties of Polydeoxyribonucleotide, a Popular Wound Healing Booster

18 citations , September 2016 in “International Journal of Molecular Sciences”

This study reports that PDRN, commonly used for wound healing, may also have anti-melanogenesis and potential skin whitening effects in both experimental models and clinical settings.

research The Antimycotic Agent Clotrimazole Inhibits Melanogenesis by Accelerating ERK and PI3K/Akt-Mediated Tyrosinase Degradation

15 citations , March 2015 in “Experimental Dermatology”

Clotrimazole, an antifungal cream, may safely reduce skin pigmentation by breaking down the enzyme needed for making melanin.

research Therapeutic Efficacy of Autologous Platelet-Rich Plasma and Polydeoxyribonucleotide on Female Pattern Hair Loss

54 citations , December 2014 in “Wound Repair and Regeneration”

This study observed that autologous PRP and PDRN injections improved hair thickness and density in women with pattern hair loss, with combined therapy showing greater improvement in thickness than PDRN alone.

research New Developments in Our Understanding of Acne Pathogenesis and Treatment

466 citations , June 2009 in “Experimental dermatology”

This review discusses recent advances in understanding acne pathobiology, highlighting the potential for developing new customized therapies, but it reports no new clinical findings.

research Follicular Miniaturization in Female Pattern Hair Loss: Clinicopathological Correlations

100 citations , June 2006 in “British Journal of Dermatology”

This study found that as hair loss severity increased in women with female pattern hair loss, the number of vellus follicles also rose, indicating miniaturization of terminal hair follicles.

research Androgenetic Alopecia in Women

139 citations , June 2003 in “Journal of Investigative Dermatology Symposium Proceedings”

This article reviews androgenetic alopecia in women, highlighting diagnosis criteria and noting that topical minoxidil is currently the only proven treatment for hair growth; it reports no clinical trial findings.