TLDR PDRN from trout sperm helps skin and hair regeneration but is costly and complex to produce.
Polydeoxyribonucleotide (PDRN), derived from trout sperm, is gaining attention in skincare and cosmetics for its regenerative properties, particularly in anti-aging, wound healing, and hair loss treatments. It stimulates collagen production, angiogenesis, and reduces inflammation, making it effective in treating acne scars and inhibiting melanogenesis. PDRN activates purinergic receptors, promoting tissue repair and regeneration, and shows promise in hair regrowth, especially when combined with platelet-rich plasma (PRP), improving hair count and thickness in female pattern hair loss patients. Despite its potential, PDRN's clinical application is limited by high costs and complex production, necessitating further research to optimize treatment protocols and explore cost-effective production methods.
18 citations,
September 2016 in “International Journal of Molecular Sciences” Polydeoxyribonucleotide (PDRN) may help lighten skin and treat hyperpigmentation.
15 citations,
March 2015 in “Experimental Dermatology” Clotrimazole, an antifungal cream, may safely reduce skin pigmentation by breaking down the enzyme needed for making melanin.
54 citations,
December 2014 in “Wound Repair and Regeneration” PRP injections may improve hair thickness and density in female hair loss patients.
466 citations,
June 2009 in “Experimental dermatology” We now understand more about what causes acne and this could lead to better, more personalized treatments.
100 citations,
June 2006 in “British Journal of Dermatology” Hair loss severity relates to increased miniaturization in female pattern hair loss.
139 citations,
June 2003 in “Journal of Investigative Dermatology Symposium Proceedings” Androgenetic alopecia in women needs more research and better management strategies.
January 2025 in “Journal of Cutaneous and Aesthetic Surgery” Low-level laser therapy effectively improves hair growth in androgenetic alopecia with minimal side effects.
July 2024 in “Periodontology 2000” Autologous platelet concentrates show promise in esthetic treatments but need more standardized research.
14 citations,
May 2021 in “Marine Drugs” PDRN, derived from salmon sperm, shows promise in healing wounds, reducing inflammation, and regenerating tissues, but more research is needed to understand its mechanisms and improve its use.
18 citations,
September 2016 in “International Journal of Molecular Sciences” Polydeoxyribonucleotide (PDRN) may help lighten skin and treat hyperpigmentation.
80 citations,
April 2017 in “Frontiers in Pharmacology” PDRN helps repair tissue and improve wound healing with a high safety profile.
