The Antimycotic Agent Clotrimazole Inhibits Melanogenesis by Accelerating ERK and PI3K/Akt-Mediated Tyrosinase Degradation

    March 2015 in “ Experimental Dermatology ”
    Bo Young Chung, Su Yeon Kim, Joon Min Jung, Chong Hyun Won, Jee Ho Choi, Mi Woo Lee, Sung Eun Chang
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    TLDR Clotrimazole, an antifungal cream, may safely reduce skin pigmentation by breaking down the enzyme needed for making melanin.
    In a 2015 study, researchers discovered that clotrimazole, an antifungal medication, can inhibit the production of melanin (melanogenesis) by promoting the breakdown of tyrosinase, an enzyme crucial for melanin synthesis. This process occurs through the activation of the ERK and Akt signaling pathways. The study, which used human and mouse melanocytes as well as B16F10 mouse melanoma cells, found that clotrimazole reduced melanin content without showing cytotoxic effects at the concentrations used. These results indicate that clotrimazole has potential as a safe topical treatment for hyperpigmentation issues. The exact number of subjects used in the study was not mentioned, as the research was conducted in vitro with cell lines.
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      community Can valisone solution cause hairloss?

      in Question  1 upvotes 7 years ago
      A user is concerned that prolonged use of valisone (betamethasone) and clotrimazole solution for scalp dermatitis may be causing hair thinning and loss. They noticed thinning in the area where the solution was applied.

      community Hair is kinking rapidly following hair loss

      in Update  1 upvotes 3 months ago
      Hair loss has slowed, but uneven growth and kinking persist despite using keto/nizoral shampoo and clotrimazole. Stress and anxiety might be contributing factors.

      community No effect Over 6 months, am I doing this wrong?

      in Update  4 upvotes 3 months ago
      The user experienced no improvement in hair loss after using a dermatologist's minoxidil 10% and finasteride 0.1% solution, clotrimazole, daily dermarolling, and multivitamins. They plan to switch to oral finasteride and reduce dermarolling to once a week.

      community Will stopping ketoconazole make a difference?

      in Ketoconazole  11 upvotes 1 year ago
      The user has been using finasteride and ketoconazole for hair loss and is considering changing shampoos due to dryness caused by ketoconazole. Responses suggest that stopping ketoconazole won't affect hair loss unless the user has seborrheic dermatitis, and recommend using conditioner or using ketoconazole shampoo less frequently.

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