The Antimycotic Agent Clotrimazole Inhibits Melanogenesis by Accelerating ERK and PI3K/Akt-Mediated Tyrosinase Degradation

    March 2015 in “ Experimental Dermatology ”
    Bo Young Chung, Su Yeon Kim, Joon Min Jung, Chong Hyun Won, Jee Ho Choi, Mi Woo Lee, Sung Eun Chang
    Image of study
    TLDR Clotrimazole, an antifungal cream, may safely reduce skin pigmentation by breaking down the enzyme needed for making melanin.
    In a 2015 study, researchers discovered that clotrimazole, an antifungal medication, can inhibit the production of melanin (melanogenesis) by promoting the breakdown of tyrosinase, an enzyme crucial for melanin synthesis. This process occurs through the activation of the ERK and Akt signaling pathways. The study, which used human and mouse melanocytes as well as B16F10 mouse melanoma cells, found that clotrimazole reduced melanin content without showing cytotoxic effects at the concentrations used. These results indicate that clotrimazole has potential as a safe topical treatment for hyperpigmentation issues. The exact number of subjects used in the study was not mentioned, as the research was conducted in vitro with cell lines.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 8 results

      community Can valisone solution cause hairloss?

      in Question  1 upvotes 6 years ago
      A user is concerned that prolonged use of valisone (betamethasone) and clotrimazole solution for scalp dermatitis may be causing hair thinning and loss. They noticed thinning in the area where the solution was applied.

      community Will stopping ketoconazole make a difference?

      in Ketoconazole  11 upvotes 8 months ago
      The user has been using finasteride and ketoconazole for hair loss and is considering changing shampoos due to dryness caused by ketoconazole. Responses suggest that stopping ketoconazole won't affect hair loss unless the user has seborrheic dermatitis, and recommend using conditioner or using ketoconazole shampoo less frequently.

      community Yeah, it’s working 👍🏻 Nov 2023 to March 2024

      in Progress Pictures  63 upvotes 9 months ago
      Animajax, who started off completely bald, has seen hair regrowth using finasteride 1.25mg, oral minoxidil 2.5mg, occasional topical minoxidil, dermastamping, benzoyl peroxide, and tretinoin. They recently added nizoral and plan to switch to a topical solution combining minoxidil and dutasteride.

      community The ultimate Regimen for density and thick ess

      in Treatment  10 upvotes 2 months ago
      The regimen for hair loss includes topical finasteride, clascoterone, tretinoin, minoxidil, oral saw palmetto, beta-sitosterol, vitamin D, microneedling, and anti-fungal shampoo. Expected benefits are increased hair growth and density, with considerations for potential skin irritation and interactions between treatments.

      community Should I start minoxidil before finasteride?

      in Treatment  3 upvotes 1 year ago
      A 21-year-old male from Bangladesh is experiencing hair loss and was advised by a dermatologist to use ketoconazole shampoo, anti-fungal treatments, biotin, and 5% minoxidil, with finasteride to be considered after six months. The user is unsure whether to follow this advice or start finasteride immediately alongside minoxidil.

    Related Research

    1 / 1 results