TLDR Plant-derived PDRN from ginseng roots effectively heals skin and improves its barrier.
This study explored the use of plant-derived polydeoxyribonucleotide (PDRN) from Korean ginseng roots as an alternative to animal-derived PDRN for skin regeneration and barrier improvement. The plant-derived PDRN was purified using microfluidization and demonstrated effectiveness in healing skin wounds and enhancing the skin barrier by promoting keratinocyte and fibroblast proliferation. It increased the expression of several proteins and acted as an agonist of the adenosine A2A receptor, activating signal transduction pathways that regenerate skin cells. These effects were confirmed in both skin cells and an artificial skin model. The study suggests that plant-derived PDRN could be a sustainable and animal-friendly option for treating skin diseases.
22 citations
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October 2018 in “Molecular Medicine Reports” Classic PDRN improves wound healing quality by enhancing cell migration.
80 citations
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April 2017 in “Frontiers in Pharmacology” PDRN helps repair tissue and improve wound healing with a high safety profile.
18 citations
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September 2016 in “International Journal of Molecular Sciences” Polydeoxyribonucleotide (PDRN) may help lighten skin and treat hyperpigmentation.
54 citations
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December 2014 in “Wound Repair and Regeneration” PRP injections may improve hair thickness and density in female hair loss patients.
September 2023 in “International journal of biological macromolecules” The chitosan/PDRN polyplex improved wound healing in diabetic rats.
18 citations
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September 2016 in “International Journal of Molecular Sciences” Polydeoxyribonucleotide (PDRN) may help lighten skin and treat hyperpigmentation.
9 citations
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January 2018 in “Plastic and Reconstructive Surgery – Global Open” Using PDRN injections and RF treatments improved revision nose surgery results without major side effects.
April 2025 in “Journal of Skin and Stem Cell” PDRN from trout sperm helps skin and hair regeneration but is costly and complex to produce.
14 citations
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May 2021 in “Marine Drugs” PDRN, derived from salmon sperm, shows promise in healing wounds, reducing inflammation, and regenerating tissues, but more research is needed to understand its mechanisms and improve its use.
