TLDR Plant-derived PDRN from ginseng roots effectively heals skin and improves its barrier.
The study evaluates the effectiveness of polydeoxyribonucleotide (PDRN) from Panax ginseng roots in skin regeneration and barrier improvement, showing it as a promising alternative to animal-derived PDRN. Using microfluidization, Panax PDRN was found to significantly enhance keratinocyte and fibroblast proliferation, activate the A2A receptor, and improve wound healing and skin barrier function in a 3D skin model. It increased trans-epidermal electrical resistance and expression of skin differentiation markers more effectively than retinoic acid, highlighting its potential for medical applications while supporting environmental and animal welfare. Future research will explore PDRN from other plants to establish PhytoPDRN as a suitable replacement.
22 citations
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October 2018 in “Molecular Medicine Reports” Classic PDRN improves wound healing quality by enhancing cell migration.
80 citations
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April 2017 in “Frontiers in Pharmacology” PDRN helps repair tissue and improve wound healing with a high safety profile.
18 citations
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September 2016 in “International Journal of Molecular Sciences” Polydeoxyribonucleotide (PDRN) may help lighten skin and treat hyperpigmentation.
54 citations
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December 2014 in “Wound Repair and Regeneration” PRP injections may improve hair thickness and density in female hair loss patients.
7 citations
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January 2025 in “Current Issues in Molecular Biology” Microbial-derived polydeoxyribonucleotide is a better and more sustainable alternative to salmon-based versions for healing and immune support.
September 2023 in “International journal of biological macromolecules” The chitosan/PDRN polyplex improved wound healing in diabetic rats.
18 citations
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September 2016 in “International Journal of Molecular Sciences” Polydeoxyribonucleotide (PDRN) may help lighten skin and treat hyperpigmentation.
9 citations
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January 2018 in “Plastic and Reconstructive Surgery – Global Open” Using PDRN injections and RF treatments improved revision nose surgery results without major side effects.
April 2025 in “Journal of Skin and Stem Cell” PDRN from trout sperm helps skin and hair regeneration but is costly and complex to produce.
