An effective range of polydeoxyribonucleotides is critical for wound healing quality

The study investigated the effects of different molecular weights of polydeoxyribonucleotides (PDRNs) on wound healing in a mouse model and found that classic PDRN (50-1,500 kDa) significantly improved the quality of wound healing. While surface wound closure did not differ significantly among the PDRNs, classic PDRN-treated mice exhibited less lipid accumulation and increased collagen composition, indicating enhanced healing quality. Classic PDRN also promoted cell migration via c-Jun N-terminal kinase signaling in human fibroblasts, suggesting its potential as a therapeutic agent for tissue regeneration by improving wound healing processes through enhanced cell migration rather than proliferation.