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This study found that repeated applications of both nonactivated and activated PRP in rats led to increased hypersensitivity to pain, which may be linked to elevated nerve growth factor levels and inflammatory mediators.

This study found that repeated PRP injections in patients with androgenetic alopecia may lead to hyperalgesia, where pain is felt with less stimulus after each treatment.

This study found that systemic ovalbumin–aluminum sensitization followed by cutaneous challenge in mice induced thermal hyperalgesia, increased spinal cord gliosis, and sprouting of nociceptive fibers, along with elevated mast cell and nerve profile densities in the skin compared to controls.

This study found that Asiasari radix extract may reduce hyperalgesia in mice by modulating NMDA and GABAA receptor activities without affecting cyclooxygenase activity.

This study found that low-intensity exercise improved pain relief in aged rats through increased brain allopregnanolone levels, while high-intensity exercise was effective in both adult and aged rats via a different mechanism.