Summation and Recommendations for the Safe and Effective Use of Topical and Oral Minoxidil

    Elise A. Olsen, Rodney Sinclair, Maria Hordinsky … Wilma F. Bergfeld
    Studysummary This source provides an overview of expert practices for using topical and low-dose oral minoxidil in treating hair loss, highlighting how dermatologists apply existing literature to ensure safe and effective treatment.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 60

    1. The Role of Patient and Drug-Related Factors in Oral Minoxidil and Pericardial Effusion: Analyses of Data From the United States Food and Drug Administration Adverse Event Reporting System Journal of Cosmetic Dermatology · 2024
    2. Evaluation of Pericardial Effusions in Alopecia Patients on Low-Dose Oral Minoxidil Therapy Journal of Drugs in Dermatology · 2024
    3. Evaluation of the Safety and Effectiveness of Oral Minoxidil in Children: A Systematic Review Dermatology and therapy · 2024
    4. Intradermal Delivery of Alopecia Therapeutics: Current State and Future Prospects Dermatologic Surgery · 2023
    5. Systemic Minoxidil for Hair Disorders in Pediatric Patients: A Safety and Tolerability Review International Journal of Dermatology · 2022
    6. Before-After Study With 24-Hour Ambulatory Blood Pressure Monitoring After the First Dose of 5 Mg Oral Minoxidil Journal of The American Academy of Dermatology · 2022
    7. Pericardial, Pleural Effusion and Anasarca: A Rare Complication of Low-Dose Oral Minoxidil for Hair Loss JAAD case reports · 2022
    8. Efficacy and Safety of 5% Minoxidil Alone, Minoxidil Plus Oral Spironolactone, and Minoxidil Plus Microneedling on Female Pattern Hair Loss: A Prospective, Single-Center, Parallel-Group, Evaluator-Blinded, Randomized Trial Frontiers in Medicine · 2022
    9. Prospective Cardiovascular Evaluation with 24-Hour Holter and Ambulatory Blood Pressure Monitoring in Men Using 5-mg Oral Minoxidil for Androgenetic Alopecia Journal of The American Academy of Dermatology · 2022
    10. Low-Dose Oral Minoxidil for Treatment of Androgenetic Alopecia and Telogen Effluvium in a Pediatric Population: A Descriptive Study Journal of The American Academy of Dermatology · 2022
    11. Sublingual Minoxidil for the Treatment of Male and Female Pattern Hair Loss: A Randomized, Double-Blind, Placebo-Controlled, Phase 1B Clinical Trial Journal of The European Academy of Dermatology and Venereology · 2021
    12. SULT1A1 (Minoxidil Sulfotransferase) Enzyme Booster Significantly Improves Response to Topical Minoxidil for Hair Regrowth Journal of Cosmetic Dermatology · 2021
    13. Low-Level Light Therapy Downregulates Scalp Inflammatory Biomarkers in Men With Androgenetic Alopecia and Boosts Minoxidil 2% for Sustainable Hair Regrowth Lasers in Surgery and Medicine · 2021
    14. Review of Oral Minoxidil as Treatment of Hair Disorders: In Search of the Perfect Dose 2021
    15. Comparison of 5% Minoxidil Lotion Monotherapy Versus Its Combination with Autologous Platelet-Rich Plasma in Androgenetic Alopecia in One Hundred Males Medical journal, Armed Forces India · 2021
    16. Safety of Low-Dose Oral Minoxidil for Hair Loss: A Multicenter Study of 1404 Patients Journal of The American Academy of Dermatology · 2021
    17. Combination Oral Minoxidil and Spironolactone for the Treatment of Androgenetic Alopecia in Adolescent Girls Journal of The American Academy of Dermatology · 2020
    18. Adverse Effects of Low-Dose Oral Minoxidil for Androgenetic Alopecia in 435 Patients Journal of The American Academy of Dermatology · 2020
    19. Low-Dose Oral Minoxidil for Treating Alopecia: A 3-Year North American Retrospective Case Series Journal of The American Academy of Dermatology · 2020
    20. Characterization and Management of Hypertrichosis Induced by Low-Dose Oral Minoxidil in the Treatment of Hair Loss Journal of The American Academy of Dermatology · 2020
    21. Low-Dose Oral Minoxidil as Treatment for Non-Scarring Alopecia: A Systematic Review International Journal of Dermatology · 2020
    22. Minoxidil Induced Central Serous Chorioretinopathy Treated with Oral Eplerenone – A Case Report BMC Ophthalmology · 2020
    23. How Safe Is Prescribing Oral Minoxidil in Patients Allergic to Topical Minoxidil? Journal of The American Academy of Dermatology · 2020
    24. Minoxidil 1 mg Oral Versus Minoxidil 5% Topical Solution for the Treatment of Female-Pattern Hair Loss: A Randomized Clinical Trial Journal of The American Academy of Dermatology · 2019
    25. Pediatric Androgenetic Alopecia: A Review Journal of The American Academy of Dermatology · 2019
    26. Off-Label Use of Topical Minoxidil in Alopecia: A Review American Journal of Clinical Dermatology · 2019
    27. Characterization of Follicular Minoxidil Sulfotransferase Activity in a Cohort of Pattern Hair Loss Patients from the Indian Subcontinent Dermatologic Therapy · 2018
    28. Low-Dose Daily Aspirin Reduces Topical Minoxidil Efficacy in Androgenetic Alopecia Patients Dermatologic Therapy · 2018
    29. The Hair Shedding Visual Scale: A Quick Tool to Assess Hair Loss in Women Dermatology and Therapy · 2017
    30. Minoxidil Topical Treatment May Be More Efficient If Applied on Damp Scalp Compared to Dry Scalp Dermatologic Therapy · 2016
    31. Hair Shedding in Women: How Much Is Too Much? British Journal of Dermatology · 2015
    32. Similar Response Patterns to Topical Minoxidil Foam 5% in Frontal and Vertex Scalp of Men with Androgenetic Alopecia: A Microarray Analysis British Journal of Dermatology · 2014
    33. Topical Minoxidil Treatment for Congenital Alopecia in Hypohidrotic Ectodermal Dysplasia 2013
    34. Central Chorioretinopathy Associated with Topical Use of Minoxidil 2% for Treatment of Baldness Cutaneous and Ocular Toxicology · 2011
    35. A Multicenter, Randomized, Placebo-Controlled, Double-Blind Clinical Trial of a Novel Formulation of 5% Minoxidil Topical Foam Versus Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2007
    36. Topical Use of Minoxidil in Children and Systemic Side Effects Dermatology · 2007
    37. Short Anagen Syndrome Journal of The American Academy of Dermatology · 2005
    38. A Randomized, Placebo-Controlled Trial of 5% and 2% Topical Minoxidil Solutions in the Treatment of Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2004
    39. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    40. Pseudoacromegaly Induced by the Long-Term Use of Minoxidil Journal of The American Academy of Dermatology · 2003
    41. Hypertrichosis in Females Applying Minoxidil Topical Solution and in Normal Controls Journal of The European Academy of Dermatology and Venereology · 2003
    42. A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2002
    43. Is Loose Anagen Hair Syndrome a Keratin Disorder? Archives of Dermatology · 2002
    44. A Randomized Trial of Minoxidil in Chemotherapy-Induced Alopecia Journal of The American Academy of Dermatology · 1996
    45. Androgenetic Alopecia in the Female Archives of Dermatology · 1994
    46. Use of Topical Minoxidil Therapy for Androgenetic Alopecia in Women International Journal of Dermatology · 1993
    47. Potassium Channel Conductance as a Control Mechanism in Hair Follicles Journal of Investigative Dermatology · 1993
    48. Minoxidil Sulfate Is the Active Metabolite That Stimulates Hair Follicles Journal of Investigative Dermatology · 1990
    49. Relationship Between Contact Time of Applied Dose and Percutaneous Absorption of Minoxidil From a Topical Solution Journal of Pharmaceutical Sciences · 1990
    50. Five-Year Follow-Up of Men with Androgenetic Alopecia Treated with Topical Minoxidil Journal of The American Academy of Dermatology · 1990
    51. Influence of Tretinoin on the Percutaneous Absorption of Minoxidil from an Aqueous Topical Solution Clinical Pharmacology & Therapeutics · 1990
    52. Minoxidil Dermatologic Clinics · 1987
    53. Topical Minoxidil in Male Pattern Baldness: Effects of Discontinuation of Treatment Journal of The American Academy of Dermatology · 1987
    54. Double-Blind, Placebo-Controlled Evaluation of Topical Minoxidil in Extensive Alopecia Areata Journal of The American Academy of Dermatology · 1987
    55. Long-Term Follow-Up of Men with Male Pattern Baldness Treated with Topical Minoxidil Journal of The American Academy of Dermatology · 1987
    56. Effects of Minoxidil on Cultured Human Skin Fibroblasts Dermatology · 1987
    57. Dose-Response Study of Topical Minoxidil in Male Pattern Baldness Journal of The American Academy of Dermatology · 1986
    58. Topical Minoxidil in Early Male Pattern Baldness Journal of The American Academy of Dermatology · 1985
    59. Percutaneous Absorption of Minoxidil in Humans Archives of Dermatology · 1985
    60. Minoxidil Annals of Internal Medicine · 1981

    Related research 1

    1. Minoxidil Sulfotransferase Enzymatical Activity in Plants: A Novel Paradigm in Increasing Minoxidil Response in Androgenetic Alopecia Journal of Cosmetic Dermatology · 2023