Intradermal Delivery of Alopecia Therapeutics: Current State and Future Prospects

June 2023 in “ Dermatologic Surgery ”

Lina Alhanshali, Michael Buontempo, Daniela Majerson, Jerry Shapiro, Kristen Lo Sicco

mesotherapy transdermal microinjections alopecia dutasteride minoxidil androgenetic alopecia Rogaine

From the encyclopedia

Mesotherapy →

technique to inject very small amounts of beneficial chemicals into the scalp

Dutasteride →

Heavy duty finasteride that comes with higher risks

Minoxidil →

An essential vasodilator with some anti-androgenic effects

Studysummary This review highlights the promising potential of mesotherapy for delivering dutasteride and minoxidil as treatments for androgenetic alopecia, emphasizing the need for more research on drug preparation, delivery, and maintenance to establish its safety and effectiveness.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The review article "Intradermal Delivery of Alopecia Therapeutics: Current State and Future Prospects" discusses the use of mesotherapy, a technique of transdermal microinjections, for alopecia treatment. The authors highlight that this method is gaining popularity due to its targeted drug delivery and minimal systemic side effects. The review indicates that recent studies show promise for the intradermal delivery of dutasteride and minoxidil in treating androgenetic alopecia. However, there are limitations with these therapies, and further research is needed to understand the preparation, delivery, and maintenance of these drugs. The authors suggest that mesotherapy could potentially become a safe, effective, and viable treatment option for androgenetic alopecia with more research.

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12 / 12 results

research Current Application of Mesotherapy in Pattern Hair Loss: A Systematic Review

8 citations , March 2022 in “Journal of Cosmetic Dermatology”

This study concluded that mesotherapy appears effective for treating pattern hair loss, but emphasizes a need for more research comparing it to other treatments due to limited sample sizes.

research Two Cases of Paradoxical Nonscarring Alopecia After Mesotherapy with Dutasteride

August 2021 in “Skin appendage disorders”

This case report highlights two instances of patchy alopecia occurring after mesotherapy with dutasteride, illustrating a possible paradoxical side effect of this treatment for androgenetic alopecia.

research Safety of Low-Dose Oral Minoxidil for Hair Loss: A Multicenter Study of 1404 Patients

39 citations , February 2021 in “Journal of The American Academy of Dermatology”

In this study, low-dose oral minoxidil for hair loss was associated with infrequent systemic adverse effects, and only 1.7% of patients discontinued treatment due to these effects.

research Effective Strategies to Reduce Pain During Platelet-Rich Plasma Scalp Injections: A Randomized Split-Scalp Study

1 citations , February 2021

This study observed that using ice pack compression or a vibration anesthesia device reduced pain during inactivated PRP scalp injections in patients with alopecia, suggesting both as inexpensive and accessible pain-relief options.

research Trichoscopic Findings in Androgenetic Alopecia

3 citations , January 2021 in “Medicinski arhiv”

In this study, trichoscopic examination revealed that patients with androgenetic alopecia had significantly more yellow dots, pilosebaceous units with one hair, and increased perifollicular hyperpigmentation compared to healthy controls.

research Intradermal Injections With 0.5% Minoxidil for the Treatment of Female Androgenetic Alopecia: A Randomized, Placebo-Controlled Trial

7 citations , December 2020 in “Dermatologic Therapy”

In this study, intradermal injections of 0.5% minoxidil significantly improved hair growth and volume in women with female androgenetic alopecia compared to a placebo, with a good safety profile reported.

research Comparative Study Between Mesotherapy and Topical 5% Minoxidil by Dermoscopic Evaluation for Androgenic Alopecia in Males: A Randomized Controlled Trial

11 citations , January 2019 in “International Journal of Trichology”

This study observed no significant improvement of mesotherapy over 5% topical minoxidil for male androgenic alopecia, despite a small increase in hair shaft diameter variation with mesotherapy.

research Mesotherapy with Dutasteride in the Treatment of Androgenetic Alopecia

24 citations , January 2017 in “International Journal of Trichology”

research Evaluation of the Effect of Injection of Dutasteride as a Mesotherapeutic Tool in the Treatment of Androgenetic Alopecia in Males

17 citations , January 2013 in “Our Dermatology Online”

This study concluded that mesotherapy with a dutasteride-containing solution was the most effective option for treating androgenetic alopecia in males, promoting hair growth and reducing hair loss.

Mesotherapy Using Dutasteride-Containing Preparation in Treatment of Female Pattern Hair Loss: Photographic, Morphometric and Ultrastructural Evaluation

research Mesotherapy Using Dutasteride-Containing Preparation in Treatment of Female Pattern Hair Loss: Photographic, Morphometric and Ultrastructural Evaluation

41 citations , April 2012 in “Journal of The European Academy of Dermatology and Venereology”

This study found that mesotherapy with a dutasteride-containing preparation improved hair growth indicators in female pattern hair loss better than saline, with minimal side effects and greater effectiveness in patients with shorter disease duration.

research Androgenetic Alopecia: Clinical Features, Classification, and Treatments

103 citations , June 2007 in “Endocrinology and Metabolism Clinics of North America”

This article discusses treatment options for androgenetic alopecia, noting that medical interventions like finasteride and minoxidil can halt and partially reverse hair loss in mild to moderate cases, especially when combined with surgery.

A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men

research A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men

269 citations , August 2002 in “Journal of The American Academy of Dermatology”

This study found that 5% topical minoxidil significantly increased hair regrowth and improved psychosocial perceptions of hair loss in men with androgenetic alopecia compared to 2% topical minoxidil and placebo over 48 weeks.