Intradermal Delivery of Alopecia Therapeutics: Current State and Future Prospects

June 2023 in “ Dermatologic Surgery ”

Lina Alhanshali, Michael Buontempo, Daniela Majerson, Jerry Shapiro, Kristen Lo Sicco

mesotherapy transdermal microinjections alopecia dutasteride minoxidil androgenetic alopecia Rogaine

TLDR New injection methods for hair loss treatment show promise but need more research.

The review article "Intradermal Delivery of Alopecia Therapeutics: Current State and Future Prospects" discusses the use of mesotherapy, a technique of transdermal microinjections, for alopecia treatment. The authors highlight that this method is gaining popularity due to its targeted drug delivery and minimal systemic side effects. The review indicates that recent studies show promise for the intradermal delivery of dutasteride and minoxidil in treating androgenetic alopecia. However, there are limitations with these therapies, and further research is needed to understand the preparation, delivery, and maintenance of these drugs. The authors suggest that mesotherapy could potentially become a safe, effective, and viable treatment option for androgenetic alopecia with more research.

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Research cited in this study

12 / 12 results

research Current Application of Mesotherapy in Pattern Hair Loss: A Systematic Review

8 citations, March 2022 in “Journal of Cosmetic Dermatology”

Mesotherapy might help with hair loss but more research is needed.

research Two Cases of Paradoxical Nonscarring Alopecia After Mesotherapy with Dutasteride

August 2021 in “Skin appendage disorders”

Two people lost hair unexpectedly after getting a common hair loss treatment with a drug called Dutasteride.

research Safety of Low-Dose Oral Minoxidil for Hair Loss: A Multicenter Study of 1404 Patients

39 citations, February 2021 in “Journal of The American Academy of Dermatology”

Low-dose oral minoxidil safely treats hair loss, with hypertrichosis as main side effect.

research Effective Strategies to Reduce Pain During Platelet-Rich Plasma Scalp Injections: A Randomized Split-Scalp Study

1 citations, February 2021

Ice packs and vibration devices can reduce pain during scalp injections.

research Trichoscopic Findings in Androgenetic Alopecia

3 citations, January 2021 in “Medicinski arhiv”

Trichoscopy, a hair loss evaluation technique, found that people with Androgenetic Alopecia have more thin hairs, yellow dots, and perifollicular discoloration than healthy individuals.

research Intradermal Injections With 0.5% Minoxidil for the Treatment of Female Androgenetic Alopecia: A Randomized, Placebo-Controlled Trial

7 citations, December 2020 in “Dermatologic Therapy”

Injections with 0.5% minoxidil effectively treat female hair loss, increasing hair density and thickness.

research Comparative Study Between Mesotherapy and Topical 5% Minoxidil by Dermoscopic Evaluation for Androgenic Alopecia in Males: A Randomized Controlled Trial

11 citations, January 2019 in “International Journal of Trichology”

Mesotherapy is not significantly better than minoxidil for treating male hair loss.

research Mesotherapy with Dutasteride in the Treatment of Androgenetic Alopecia

24 citations, January 2017 in “International Journal of Trichology”

research Evaluation of the Effect of Injection of Dutasteride as a Mesotherapeutic Tool in the Treatment of Androgenetic Alopecia in Males

17 citations, January 2013 in “Our Dermatology Online”

Dutasteride mesotherapy helps treat male hair loss but may harm sperm and sexual function.

Mesotherapy Using Dutasteride-Containing Preparation in Treatment of Female Pattern Hair Loss: Photographic, Morphometric and Ultrastructural Evaluation

research Mesotherapy Using Dutasteride-Containing Preparation in Treatment of Female Pattern Hair Loss: Photographic, Morphometric and Ultrastructural Evaluation

41 citations, April 2012 in “Journal of The European Academy of Dermatology and Venereology”

Dutasteride-containing mesotherapy effectively treats female hair loss, improving density and thickness with minimal side effects.

research Androgenetic Alopecia: Clinical Features, Classification, and Treatments

103 citations, June 2007 in “Endocrinology and Metabolism Clinics of North America”

Male pattern hair loss is genetic and influenced by hormones, with treatments like minoxidil and surgery available.

A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men

research A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men

269 citations, August 2002 in “Journal of The American Academy of Dermatology”

5% minoxidil works better for hair growth and density, with minor irritation.

Related Research

6 / 6 results

research Evaluation of Hair Regrowth After Minoxidil and Dutasteride Tattooing in Men with Androgenetic Alopecia

May 2023 in “JAAD international”

Minoxidil-dutasteride tattooing can potentially help regrow hair, especially in men who already have some thin hair.

research Combination Therapy with Oral Minoxidil and Dutasteride in the Treatment of Male Patterned Baldness: A Case Report

January 2022 in “Cosmoderma”

Using oral minoxidil and dutasteride together can quickly increase hair growth and volume with minimal side effects.

Intradermal Delivery of Alopecia Therapeutics: Current State and Future Prospects

Research cited in this study

research Current Application of Mesotherapy in Pattern Hair Loss: A Systematic Review

research Two Cases of Paradoxical Nonscarring Alopecia After Mesotherapy with Dutasteride

research Safety of Low-Dose Oral Minoxidil for Hair Loss: A Multicenter Study of 1404 Patients

research Effective Strategies to Reduce Pain During Platelet-Rich Plasma Scalp Injections: A Randomized Split-Scalp Study

research Trichoscopic Findings in Androgenetic Alopecia

research Intradermal Injections With 0.5% Minoxidil for the Treatment of Female Androgenetic Alopecia: A Randomized, Placebo-Controlled Trial

research Comparative Study Between Mesotherapy and Topical 5% Minoxidil by Dermoscopic Evaluation for Androgenic Alopecia in Males: A Randomized Controlled Trial

research Mesotherapy with Dutasteride in the Treatment of Androgenetic Alopecia

research Evaluation of the Effect of Injection of Dutasteride as a Mesotherapeutic Tool in the Treatment of Androgenetic Alopecia in Males

research Mesotherapy Using Dutasteride-Containing Preparation in Treatment of Female Pattern Hair Loss: Photographic, Morphometric and Ultrastructural Evaluation

research Androgenetic Alopecia: Clinical Features, Classification, and Treatments

research A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men

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research Combination Therapy with Oral Minoxidil and Dutasteride in the Treatment of Male Patterned Baldness: A Case Report

research LB792 Minoxidil and Dutasteride Drug Tattooing for Male Androgenetic Alopecia

research Mesotherapy with Dutasteride and Minoxidil in the Treatment of Androgenetic Alopecia

research Minoxidil-Induced Hypertrichosis in a Child with Alopecia Areata

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