Two Cases of Paradoxical Nonscarring Alopecia After Mesotherapy with Dutasteride

    August 2021 in “ Skin appendage disorders ”
    Leandra Reguero del Cura, Adrian De Quintana Sancho, Marta Millan Lombraña, Ana Elisabet López Sundh, Marcos Pérez López
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    TLDR Two people lost hair unexpectedly after getting a common hair loss treatment with a drug called Dutasteride.
    The document presents two cases of paradoxical nonscarring alopecia following mesotherapy with dutasteride, a treatment for hair fall that involves microinjection of the drug into the dermis. Dutasteride is a second-generation 5a-reductase enzyme inhibitor that decreases serum dihydrotestosterone levels by 90%. It inhibits both type 1 and 2 enzymes, while finasteride inhibits only type 2. While mesotherapy with dutasteride is becoming increasingly common and usually has only mild transitory side effects at the injection site, these two cases (one male and one female with androgenetic alopecia) developed patchy alopecia after treatment. One of them also developed skin atrophy on the affected areas without improvement at short term follow-up. These cases highlight the potential paradoxical side effects of mesotherapy as a therapeutic technique for hair loss.
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      community How is there still no consensus on Topical Dutasteride in 2024?

      in Finasteride/Dutasteride  147 upvotes 1 year ago
      The conversation expresses frustration over the lack of clear evidence regarding the effectiveness and systemic impact of topical Dutasteride for hair loss treatment, despite years of discussion. People are criticized for not conducting proper research and for providing contradictory anecdotal claims.

      community Dutasteride mesotherapy where to buy

      in Finasteride/Dutasteride  3 upvotes 2 weeks ago
      The conversation is about purchasing dutasteride solution for mesotherapy, with a suggestion to make it using dutasteride capsules and oils. A user shared a link to a potential supplier and mentioned using dutasteride with microneedling.

      community Dutasteride mesotherapy help me !

      in Finasteride/Dutasteride  2 upvotes 2 months ago
      The user experienced side effects like watery semen, erection problems, and decreased libido from finasteride, which resolved after stopping it. They are considering dutasteride mesotherapy as an alternative, as advised by their dermatologist, and are concerned about potential side effects.

      community Dutasteride Mesotherapy worth it?

      in Finasteride/Dutasteride  2 upvotes 2 months ago
      Dutasteride mesotherapy is being considered for hair regrowth, with one user reporting significant success when combined with oral dutasteride, oral and topical minoxidil, and vitamins. Another user suggests using topical finasteride and oral dutasteride instead, as mesotherapy results are inconclusive.

      community Dutasteride mesotherapy to lower dut dose

      in Finasteride/Dutasteride  1 upvotes 3 months ago
      The conversation is about a user considering reducing their dutasteride dose due to side effects like lower libido and watery semen. They plan to use dutasteride mesotherapy every three months to maintain hair while reducing systemic DHT suppression.

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