Percutaneous Absorption of Minoxidil in Humans

    February 1985 in “ Archives of Dermatology
    Thomas Franz
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    TLDR Minoxidil absorbs poorly through skin, with low risk of side effects at 1-2% concentration.
    The study aimed to determine the extent of percutaneous absorption of minoxidil in humans. The results showed that topically applied minoxidil is poorly absorbed through the skin, with only 1.6% to 3.9% of the applied dose being absorbed. The study also found that the scalp is not as permeable as previously thought. The data allowed for an estimation of the magnitude of minoxidil absorption under various clinical conditions, and it was concluded that applications of minoxidil at a 1% to 2% concentration to 50% of the scalp or less are unlikely to cause systemic side effects. The study did not find any adverse reactions or substantial laboratory abnormalities in the subjects during the study.
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      community Reasons why Topical worked but Oral Minoxidil didn’t?

      in Minoxidil  16 upvotes 1 year ago
      Some people find topical minoxidil effective for hair loss, but oral minoxidil doesn't work for them, possibly due to absorption issues. Others have had better results with oral minoxidil, suggesting individual responses vary.

      community Minoxidil its giving me huge water retention

      in Minoxidil  128 upvotes 3 days ago
      Minoxidil caused water retention and gastrointestinal issues for the user, which improved after stopping the medication. The user is now using finasteride and topical minoxidil, experiencing excessive urination and concerns about systemic absorption.

      community Should I add oral minoxidil right now?

      in Minoxidil  85 upvotes 2 weeks ago
      The user is considering adding oral minoxidil to their current hair loss treatment, which includes dutasteride and occasional finasteride, due to concerns about hair thinning and potential shedding. They are unsure if starting both treatments simultaneously could worsen shedding or if oral minoxidil might be beneficial.

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