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Skin-Permeable Liposome Improved Stability and Permeability of bFGF Against Skin of Mice With Deep Second-Degree Scald to Promote Hair Follicle Neogenesis Through Inhibition of Scar Formation

research Skin-permeable liposome improved stability and permeability of bFGF against skin of mice with deep second degree scald to promote hair follicle neogenesis through inhibition of scar formation

26 citations , September 2018 in “Colloids and Surfaces B: Biointerfaces”

This study reported that a novel liposomal formulation, SP-bFGF-SF-LIP, enhanced bFGF stability and skin permeability, significantly improving hair follicle recovery and wound healing in a mouse model.

research Effect of Nymphaea caerulea Flower Extract on Improving Scalp Diseases

March 2024 in “Korean Journal of Pharmacognosy”

This study found that Nymphaea caerulea flower extract may improve scalp condition by reducing sebum production, inhibiting inflammation and microbial factors, and decreasing cortisol and vascular permeability.

Percutaneous Absorption of Minoxidil in Humans

research Percutaneous Absorption of Minoxidil in Man

52 citations , February 1985 in “Archives of Dermatology”

Minoxidil absorbs poorly through skin, with low risk of side effects at 1-2% concentration.

Nanocarriers for Optimizing the Balance Between Interfollicular Permeation and Follicular Uptake of Topically Applied Clobetasol to Minimize Adverse Effects

research Nanocarriers for optimizing the balance between interfollicular permeation and follicular uptake of topically applied clobetasol to minimize adverse effects

69 citations , December 2015 in “Journal of Controlled Release”

This study found that nanocapsules formulated as a dispersion and applied with massage may enhance follicular uptake of clobetasol propionate while minimizing its skin penetration, offering a potential improvement over conventional treatments for scalp diseases.

research Influence of tretinoin on the percutaneous absorption of minoxidil from an aqueous topical solution

30 citations , April 1990 in “Clinical Pharmacology & Therapeutics”

This study found that coadministering minoxidil with tretinoin cream increased minoxidil absorption nearly threefold in healthy males, attributed to increased stratum corneum permeability.

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community Tretinoin can enhance the skin permeability of Minoxidil approximately 3-fold at 0.05%[24] and itself has some hair regrowth properties.

7 upvotes 11 years ago

The conversation discusses enhancing Minoxidil absorption for hair loss treatment using Tretinoin and MSM (Methylsulfonylmethane). The user is seeking sources for Tretinoin and mentions MSM's potential to improve the absorption of topical agents.

community Switching RU vehicle due to scalp irritation – anyone tried low-EtOH + squalane / emu oil?

in Treatment 2 upvotes 9 months ago

The user is experiencing scalp irritation from using RU58841 with a 70% ethanol and 30% propylene glycol vehicle and is considering switching to a less irritating vehicle, such as 30% ethanol with 70% squalane or emu oil. They are seeking feedback on the effectiveness and irritation levels of these alternative carriers.

community Did Tretinoin turn you into a minoxidil responder after not responding to minoxidil?

20 upvotes 1 year ago

Tretinoin may enhance the effectiveness of minoxidil for hair regrowth by increasing enzyme activity and skin permeability, but its standalone impact is limited. Some users experienced improved hair growth with tretinoin, while others found it worsened their condition.

community I think microneedling before topical application of finasteride (or dut) is a path we should investigate (for those of us who don't care about systemic absorption). Here's why...

20 upvotes 1 year ago

Microneedling before applying topical finasteride or dutasteride may enhance their effectiveness by increasing local absorption in the scalp, despite concerns about systemic absorption. Users discuss combining this method with oral treatments and minoxidil, noting potential benefits and side effects.