Efficacy and Safety of 5% Minoxidil Alone, Minoxidil Plus Oral Spironolactone, and Minoxidil Plus Microneedling on Female Pattern Hair Loss: A Prospective, Single-Center, Parallel-Group, Evaluator-Blinded, Randomized Trial

    July 2022 in “ Frontiers in Medicine ”
    Xuelei Liang, Yuan Chang, Hai-Xuan Wu … Fenglin Zhuo
    Studysummary This study found that combining topical minoxidil with microneedling improved hair density more than either minoxidil alone or with spironolactone for women with mild-to-moderate female pattern hair loss.
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    Research cited in this study 28

    1. Health-Related Quality of Life, Depression, and Self-Esteem in Patients With Androgenetic Alopecia JAMA Dermatology · 2021
    2. A Pilot Evaluation of Scalp Skin Wounding to Promote Hair Growth in Female Pattern Hair Loss International Journal of Women's Dermatology · 2020
    3. Androgenetic Alopecia in Women and Men: Italian Guidelines Adapted from European Dermatology Forum/European Academy of Dermatology and Venereology Guidelines Giornale italiano di dermatologia e venereologia · 2020
    4. Female Pattern Hair Loss: A Comprehensive Review Dermatologic Therapy · 2020
    5. Spironolactone for Treatment of Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2020
    6. Minoxidil 1 mg Oral Versus Minoxidil 5% Topical Solution for the Treatment of Female-Pattern Hair Loss: A Randomized Clinical Trial Journal of The American Academy of Dermatology · 2019
    7. Androgens in Women: Hormone-Modulating Therapies for Androgen-Mediated Cutaneous Disorders Journal of The American Academy of Dermatology · 2018
    8. Female Pattern Hair Loss: A Clinical, Pathophysiologic, and Therapeutic Review International Journal of Women's Dermatology · 2018
    9. Microneedling for the Treatment of Hair Loss Journal of The European Academy of Dermatology and Venereology · 2017
    10. Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men – Short Version Journal of The European Academy of Dermatology and Venereology · 2017
    11. Randomized Trial of Electrodynamic Microneedle Combined with 5% Minoxidil Topical Solution for the Treatment of Chinese Male Androgenetic Alopecia Journal of Cosmetic and Laser Therapy · 2017
    12. Review of Applications of Microneedling in Dermatology Clinical, Cosmetic and Investigational Dermatology · 2017
    13. Interventions for Female Pattern Hair Loss JAMA Dermatology · 2017
    14. Pigmentation of Regenerated Hairs After Wounding Journal of Dermatological Science · 2016
    15. Response to Microneedling Treatment in Men with Androgenetic Alopecia Who Failed to Respond to Conventional Therapy Indian Journal of Dermatology · 2015
    16. Hair Shedding in Women: How Much Is Too Much? British Journal of Dermatology · 2015
    17. A Randomized Evaluator Blinded Study of Effect of Microneedling in Androgenetic Alopecia: A Pilot Study International Journal of Trichology · 2013
    18. A Randomized, Single-Blind Trial of 5% Minoxidil Foam Once Daily Versus 2% Minoxidil Solution Twice Daily in the Treatment of Androgenetic Alopecia in Women Journal of The American Academy of Dermatology · 2011
    19. Prevalence of Androgenetic Alopecia in China: A Community-Based Study in Six Cities British Journal of Dermatology · 2010
    20. Treatment of Female Pattern Hair Loss with a Combination of Spironolactone and Minoxidil Australasian Journal of Dermatology · 2007
    21. Treatment of Female Pattern Hair Loss With Oral Antiandrogens British Journal of Dermatology · 2005
    22. A Randomized, Placebo-Controlled Trial of 5% and 2% Topical Minoxidil Solutions in the Treatment of Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2004
    23. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    24. A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2002
    25. The Prevalence and Types of Androgenetic Alopecia in Korean Men and Women British Journal of Dermatology · 2001
    26. Incidence of Female Androgenetic Alopecia (Female Pattern Alopecia) Dermatologic Surgery · 2001
    27. Incidence of Female Androgenetic Alopecia (Female Pattern Alopecia) Dermatologic Surgery · 2001
    28. Development of a Health-Related Quality of Life Questionnaire for Women with Androgenetic Alopecia Clinical and Experimental Dermatology · 2000

    Related research 10

    1. A Survey of Patient Attitudes Towards Topical Minoxidil in the Treatment of Hair Loss PubMed · 2022
    2. Sisaipho Alopecia Areata Treated With Tofacitinib and Oral Minoxidil JAAD case reports · 2022
    3. Scalp Threading – New Treatment Option for Androgenetic Alopecia South Florida Journal of Health · 2022
    4. Scalp Vascularization as a Marker of Topical Minoxidil Treatment Efficacy in Patients with Androgenetic Alopecia Postepy Dermatologii I Alergologii · 2021
    5. Sulfotransferase SULT1A1 Activity in Hair Follicle: A Prognostic Marker of Response to Minoxidil Treatment in Androgenetic Alopecia Postepy Dermatologii I Alergologii · 2020
    6. Efficacy of Systemic Minoxidil and Tofacitinib Combination in Treatment-Resistant Alopecia Universalis Journal of Cosmetic Dermatology · 2020
    7. Hair Disorders Oxford University Press eBooks · 2018
    8. Pustular Dermatosis of the Scalp Due to Topical Minoxidil 5% 2018
    9. Scalp Psoriasiform Contact Dermatitis with Acute Telogen Effluvium Due to Topical Minoxidil Treatment Skin appendage disorders · 2015
    10. Disorders of Hair DeckerMed Medicine · 2013