Adverse Effects of Low-Dose Oral Minoxidil for Androgenetic Alopecia in 435 Patients

November 2020 in “ Journal of The American Academy of Dermatology ”

Baltazar Dias Sanabria, Tamara de Nardo Vanzela, Hélio Amante Miot, Paulo Müller Ramos

minoxidil androgenetic alopecia hypertrichosis hypotension tachycardia edema headache insomnia nightmares Rogaine

TLDR Low-dose oral minoxidil may cause side effects like hypertrichosis and is not suitable for everyone.

The study examined the adverse effects of low-dose oral minoxidil for androgenetic alopecia in 435 patients. The most common adverse effect reported was hypertrichosis, which was associated with younger age and dose/weight in men. Other adverse effects included hypotension, tachycardia, edema, headache, insomnia, and nightmares. The study suggests that low-dose oral minoxidil may not be suitable for all patients with androgenetic alopecia due to the potential for adverse effects.

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Research cited in this study

2 / 2 results

research Low-Dose Oral Minoxidil as Treatment for Non-Scarring Alopecia: A Systematic Review

19 citations, June 2020 in “International Journal of Dermatology”

Low-dose oral minoxidil effectively treats non-scarring hair loss with some side effects like hypertrichosis and postural hypotension.

A Randomized, Single-Blind Trial of 5% Minoxidil Foam Once Daily Versus 2% Minoxidil Solution Twice Daily in the Treatment of Androgenetic Alopecia in Women

research A Randomized, Single-Blind Trial of 5% Minoxidil Foam Once Daily Versus 2% Minoxidil Solution Twice Daily in the Treatment of Androgenetic Alopecia in Women

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5% minoxidil foam once daily works as well as 2% minoxidil solution twice daily for female hair growth and is more convenient.

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community The no BS guide to saving your hair without finasteride (improvement in 90% of patients in the study) with a low side effect profile or improvement in 100% of patients but a higher side effect profile and increased dosage. The future is here?

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Hair loss treatments, specifically the use of oral minoxidil in combination with micro-needling. Oral minoxidil has been found to improve hair density in 90% of patients with a low side effect profile, but using 5mg per day can result in higher side effects including hypertrichosis and edema. Other treatments mentioned include finasteride and RU58841.

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in Transgender 591 upvotes 10 months ago

The conversation discusses a transgender individual's successful hair loss treatment over 1.5 years using 2.5mg oral minoxidil, 5mg finasteride, and 8mg weekly injectable estradiol valerate. Some users debate the appropriateness of this approach within the group's goals, while others support the individualized treatment and its additional benefits for transgender individuals.

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Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

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