TLDR A 5-mg dose of oral minoxidil slightly lowers blood pressure temporarily, especially in those with higher initial blood pressure.
This study evaluated the cardiovascular effects of a 5-mg dose of oral minoxidil in 10 men with androgenetic alopecia using 24-hour ambulatory blood pressure monitoring (ABPM). Measurements were taken at baseline and after the first dose. Results showed no statistically significant differences in mean systolic blood pressure (mSBP), mean diastolic blood pressure (mDBP), and mean heart rate (mHR) over 24 hours. However, a nonsignificant reduction in mSBP and mDBP was observed within the first 2 hours post-intake, which normalized after 4 hours. Patients with higher baseline systolic blood pressure (>130 mmHg) experienced a greater reduction in BP. One patient reported lightheadedness, which resolved spontaneously. The study concludes that 5-mg minoxidil causes a slight, transient reduction in BP, particularly in patients with higher baseline BP, and suggests ABPM for patients with a history of postural hypotension before starting treatment.
3 citations,
May 2022 in “Journal of The American Academy of Dermatology” The conclusion is that 24 weeks of low-dose oral minoxidil is safe for men with hair loss, with no significant changes in heart rate or blood pressure.
24 citations,
September 2020 in “Dermatology and therapy” Oral minoxidil 5 mg daily increases hair growth safely in men with hair loss, with minor side effects.
16 citations,
May 2020 in “Journal of The European Academy of Dermatology and Venereology” Sublingual minoxidil effectively treats hair loss with mild side effects.
53 citations,
August 2019 in “Journal of The American Academy of Dermatology” Oral minoxidil and topical minoxidil 5% both effectively improve female-pattern hair loss with safe side effects.
25 citations,
February 1989 in “The Journal of Clinical Pharmacology” This document studied minoxidil in healthy volunteers. Minoxidil is quickly absorbed and eliminated from the body.
3 citations,
May 2022 in “Journal of The American Academy of Dermatology” The conclusion is that 24 weeks of low-dose oral minoxidil is safe for men with hair loss, with no significant changes in heart rate or blood pressure.
August 2023 in “JAAD International” Low dose oral minoxidil is generally safe and can improve hair loss in women, with some experiencing side effects and minimal blood pressure changes.
5 citations,
July 2016 in “Journal of Clinical Hypertension” Men with severe early-onset baldness may have worse heart artery function and stiffer arteries if they have high blood pressure.
1 citations,
March 2023 in “Nutrients” The conclusion is that obesity should be managed with a slow, balanced approach to diet and exercise, with medication and surgery as additional options, and education and access to care are important.
February 2024 in “Animals” Most dogs with adrenal-dependent hypercortisolism had normal blood pressure after one year of treatment or surgery.
